Stephan J Sigrist
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Explore the profile of Stephan J Sigrist including associated specialties, affiliations and a list of published articles.
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143
Citations
6998
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Recent Articles
1.
Karpova A, Hiesinger P, Kuijpers M, Albrecht A, Kirstein J, Andres-Alonso M, et al.
Neuron
. 2025 Feb;
PMID: 40010347
Neurons are long-lived postmitotic cells that capitalize on autophagy to remove toxic or defective proteins and organelles to maintain neurotransmission and the integrity of their functional proteome. Mutations in autophagy...
2.
Fei L, Liang Y, Kintscher U, Sigrist S
Redox Biol
. 2024 Dec;
79():103454.
PMID: 39642596
Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic...
3.
Hofer S, Daskalaki I, Bergmann M, Friscic J, Zimmermann A, Mueller M, et al.
Nat Cell Biol
. 2024 Aug;
26(9):1571-1584.
PMID: 39117797
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and...
4.
Turrel O, Gao L, Sigrist S
Learn Mem
. 2024 Jun;
31(5).
PMID: 38862173
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic...
5.
Rizalar F, Lucht M, Petzoldt A, Kong S, Sun J, Vines J, et al.
Science
. 2023 Oct;
382(6667):223-230.
PMID: 37824668
Neurons relay information via specialized presynaptic compartments for neurotransmission. Unlike conventional organelles, the specialized apparatus characterizing the neuronal presynapse must form de novo. How the components for presynaptic neurotransmission are...
6.
Ramesh N, Escher M, Turrel O, Lutzkendorf J, Matkovic T, Liu F, et al.
Elife
. 2023 Sep;
12.
PMID: 37767892
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved...
7.
Sigrist S, Haucke V
EMBO Rep
. 2023 Sep;
24(11):e57758.
PMID: 37680133
Compartmentalization by membranes is a common feature of eukaryotic cells and serves to spatiotemporally confine biochemical reactions to control physiology. Membrane-bound organelles such as the endoplasmic reticulum (ER), the Golgi...
8.
Ghelani T, Escher M, Thomas U, Esch K, Lutzkendorf J, Depner H, et al.
Sci Adv
. 2023 Feb;
9(7):eade7804.
PMID: 36800417
At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca channels (VGCCs). While AZs can potentiate...
9.
Jang W, Puchkov D, Samso P, Liang Y, Nadler-Holly M, Sigrist S, et al.
Science
. 2022 Dec;
378(6625):eabq5209.
PMID: 36520888
Cells respond to fluctuating nutrient supply by adaptive changes in organelle dynamics and in metabolism. How such changes are orchestrated on a cell-wide scale is unknown. We show that endosomal...
10.
Perry S, Han Y, Qiu C, Chien C, Goel P, Nishimura S, et al.
Nat Commun
. 2022 Dec;
13(1):7656.
PMID: 36496500
Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release following diminished postsynaptic glutamate receptor (GluR) functionality to maintain synaptic strength. While much is known about PHP expression mechanisms, postsynaptic induction remains...