Martin Klumpp
Overview
Explore the profile of Martin Klumpp including associated specialties, affiliations and a list of published articles.
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16
Citations
248
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Recent Articles
1.
Chen C, Zhu H, Stauffer F, Caravatti G, Vollmer S, Machauer R, et al.
ACS Med Chem Lett
. 2016 Aug;
7(8):735-40.
PMID: 27563395
Oncogenic MLL fusion proteins aberrantly recruit Dot1L, a histone methyltransferase, to ectopic loci, leading to local hypermethylation of H3K79 and misexpression of HoxA genes driving MLL-rearranged leukemias. Inhibition of the...
2.
Heedmann B, Klumpp M
Methods Mol Biol
. 2016 Jun;
1439:159-69.
PMID: 27316994
Autophosphorylation of kinases influences their conformational state and can also regulate enzymatic activity. Recently, this has become an area of interest for drug discovery. Using Alk2 as an example, we...
3.
Klumpp M
Expert Opin Drug Discov
. 2015 Dec;
11(2):149-62.
PMID: 26653534
Introduction: Non-stoichiometric inhibition summarizes different mechanisms by which low-molecular weight compounds can reproducibly inhibit high-throughput screening (HTS) and other lead finding assays without binding to a structurally defined site on...
4.
Wassermann A, Lounkine E, Urban L, Whitebread S, Chen S, Hughes K, et al.
ACS Chem Biol
. 2014 May;
9(7):1622-31.
PMID: 24802392
Computational target prediction methods using chemical descriptors have been applied exhaustively in drug discovery to elucidate the mechanisms-of-action (MOAs) of small molecules. To predict truly novel and unexpected small molecule-target...
5.
Cai X, Xu Y, Cheung A, Tomlinson R, Alcazar-Roman A, Murphy L, et al.
Chem Biol
. 2013 Jul;
20(7):912-21.
PMID: 23890009
Toll-like receptor (TLR) signaling is a key component of innate immunity. Aberrant TLR activation leads to immune disorders via dysregulation of cytokine production, such as IL-12/IL-23. Herein, we identify and...
6.
Klumpp M, Mayr L
Expert Opin Drug Discov
. 2013 Mar;
1(4):361-4.
PMID: 23495906
The 9th annual MipTec conference was held in Basel, Switzerland on 8 - 11 May 2006 and was preceded by a preconference including a variety of well-established speakers highlighting various...
7.
Klumpp M, Mayr L
Expert Opin Drug Discov
. 2013 Mar;
2(10):1415-9.
PMID: 23484536
The 10th anniversary of MipTec, which took place in Basel, Switzerland on 7 - 10 May 2007, demonstrated that this meeting has truly evolved into the leading European event for...
8.
Ostermann N, Ruedisser S, Ehrhardt C, Breitenstein W, Marzinzik A, Jacoby E, et al.
J Med Chem
. 2013 Jan;
56(6):2196-206.
PMID: 23360239
A small library of fragments comprising putative recognition motifs for the catalytic dyad of aspartic proteases was generated by in silico similarity searches within the corporate compound deck based on...
9.
Coan K, Ottl J, Klumpp M
Expert Opin Drug Discov
. 2012 Jun;
6(4):405-17.
PMID: 22646018
Introduction: Over the last 2 decades, high-throughput screening (HTS) has become one of the key strategies for the generation of new leads. Non-stoichiometric inhibition is one of the most extensively...
10.
Trowitzsch S, Klumpp M, Thoma R, Carralot J, Berger I
Bioessays
. 2011 Oct;
33(12):946-55.
PMID: 22002169
Multigene delivery and expression systems are emerging as key technologies for many applications in contemporary biology. We have developed new methods for multigene delivery and expression in eukaryotic hosts for...