Martin E Fernandez-Zapico
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Explore the profile of Martin E Fernandez-Zapico including associated specialties, affiliations and a list of published articles.
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173
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8659
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Recent Articles
11.
Weiz G, Gonzalez A, Mansilla I, Fernandez-Zapico M, Molejon M, Breccia J
Microb Cell Fact
. 2024 May;
23(1):133.
PMID: 38720294
Background: Low targeting efficacy and high toxicity continue to be challenges in Oncology. A promising strategy is the glycosylation of chemotherapeutic agents to improve their pharmacodynamics and anti-tumoral activity. Herein,...
12.
Xu Y, Nipper M, Dominguez A, Ye Z, Akanuma N, Lopez K, et al.
Nat Commun
. 2024 Jan;
15(1):818.
PMID: 38280869
Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains under debate. To...
13.
Hasselluhn M, Decker-Farrell A, Vlahos L, Thomas D, Curiel-Garcia A, Maurer H, et al.
Cancer Discov
. 2023 Nov;
14(2):348-361.
PMID: 37966260
Significance: We present a key mechanism of tumor angiosuppression, a process that sculpts the physiologic, cellular, and metabolic environment of PDAC. We further present a computational and experimental framework for...
14.
Gutierrez-Ruiz O, Johnson K, Krueger E, Nooren R, Cruz-Reyes N, Heppelmann C, et al.
Cell Rep
. 2023 Aug;
42(9):113042.
PMID: 37651233
Amplified lysosome activity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) orchestrated by oncogenic KRAS that mediates tumor growth and metastasis, though the mechanisms underlying this phenomenon remain unclear. Using...
15.
Paradise B, Gainullin V, Almada L, Sigafoos A, Sen S, Vera R, et al.
Biochem J
. 2023 Jul;
480(15):1199-1216.
PMID: 37477952
Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. One well-established mechanism of this...
16.
Tella S, Foster N, Qian S, Nguyen T, Borad M, McWilliams R, et al.
Oncologist
. 2023 Jun;
28(10):917-e966.
PMID: 37339254
Background: We sought to determine the safety and efficacy of trifluridine/tipiracil in combination with irinotecan in a phase II trial setting for refractory, advanced unresectable biliary tract carcinoma (BTC). Methods:...
17.
Letson C, Balasis M, Newman H, Binder M, Vedder A, Kinose F, et al.
Clin Cancer Res
. 2023 May;
29(15):2919-2932.
PMID: 37223910
Purpose: Preclinical studies in myeloid neoplasms have demonstrated efficacy of bromodomain and extra-terminal protein inhibitors (BETi). However, BETi demonstrates poor single-agent activity in clinical trials. Several studies suggest that combination...
18.
Alem D, Yang X, Beato F, Sarcar B, Tassielli A, Dai R, et al.
Mol Carcinog
. 2023 Apr;
62(7):1025-1037.
PMID: 37042566
It has been challenging to target mutant KRAS (mKRAS) in colorectal cancer (CRC) and other malignancies. Recent efforts have focused on developing inhibitors blocking molecules essential for KRAS activity. In...
19.
LaRue K, Fernandez-Zapico M
Cell Mol Gastroenterol Hepatol
. 2023 Mar;
15(5):1253-1254.
PMID: 36882150
No abstract available.
20.
Almada L, Barroso K, Sen S, Toruner M, Sigafoos A, Raja Arul G, et al.
Biochim Biophys Acta Gene Regul Mech
. 2023 Feb;
1866(2):194924.
PMID: 36842643
Upon accumulation of improperly folded proteins in the Endoplasmic Reticulum (ER), the Unfolded Protein Response (UPR) is triggered to restore ER homeostasis. The induction of stress genes is a sine...