Ashley N Sigafoos
Overview
Explore the profile of Ashley N Sigafoos including associated specialties, affiliations and a list of published articles.
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24
Citations
269
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Recent Articles
1.
LaRue-Nolan K, Raja Arul G, Sigafoos A, Shi J, Fernandez-Zapico M
Biochem J
. 2024 Jul;
481(15):983-997.
PMID: 39078225
Pancreatic cancer is a malignancy arising from the endocrine or exocrine compartment of this organ. Tumors from exocrine origin comprise over 90% of all pancreatic cancers diagnosed. Of these, pancreatic...
2.
Sigafoos A, Tolosa E, Carr R, Fernandez-Barrena M, Almada L, Pease D, et al.
Cancer Res Commun
. 2024 Jun;
4(7):1677-1689.
PMID: 38896052
Aberrant activation of GLI transcription factors has been implicated in the pathogenesis of different tumor types including pancreatic ductal adenocarcinoma. However, the mechanistic link with established drivers of this disease...
3.
Paradise B, Gainullin V, Almada L, Sigafoos A, Sen S, Vera R, et al.
Biochem J
. 2023 Jul;
480(15):1199-1216.
PMID: 37477952
Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. One well-established mechanism of this...
4.
Almada L, Barroso K, Sen S, Toruner M, Sigafoos A, Raja Arul G, et al.
Biochim Biophys Acta Gene Regul Mech
. 2023 Feb;
1866(2):194924.
PMID: 36842643
Upon accumulation of improperly folded proteins in the Endoplasmic Reticulum (ER), the Unfolded Protein Response (UPR) is triggered to restore ER homeostasis. The induction of stress genes is a sine...
5.
Klee E, Cousin M, Pinto E Vairo F, Morales-Rosado J, Macke E, Jenkinson W, et al.
Genet Med
. 2023 Feb;
25(2):100359.
PMID: 36745126
No abstract available.
6.
Vera R, Lamberti M, Almada L, Tolosa E, Vrabel A, Sigafoos A, et al.
Biochem J
. 2023 Feb;
480(3):225-241.
PMID: 36734208
Carcinoma-associated fibroblasts (CAFs) play an important role in the progression of multiple malignancies. Secretion of cytokines and growth factors underlies the pro-tumoral effect of CAFs. Although this paracrine function has...
7.
Hogenson T, Xie H, Phillips W, Toruner M, Li J, Horn I, et al.
JCI Insight
. 2022 Oct;
7(22).
PMID: 36256477
BACKGROUNDA patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO's ability to predict clinical response to gastrointestinal (GI) cancers.METHODSWe...
8.
Flores L, Tader B, Tolosa E, Sigafoos A, Marks D, Fernandez-Zapico M
Cells
. 2021 Oct;
10(10).
PMID: 34685604
Changes in nuclear shape have been extensively associated with the dynamics and functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and minimal variation in...
9.
Sigafoos A, Paradise B, Fernandez-Zapico M
Cancers (Basel)
. 2021 Jul;
13(14).
PMID: 34298625
The Hh/GLI signaling pathway was originally discovered in as a major regulator of segment patterning in development. This pathway consists of a series of ligands (Shh, Ihh, and Dhh), transmembrane...
10.
Ferrer A, Mangaonkar A, Stroik S, Zimmermann M, Sigafoos A, Kamath P, et al.
Blood Cancer J
. 2020 Nov;
10(11):120.
PMID: 33203829
No abstract available.