Martin A Hayes
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Explore the profile of Martin A Hayes including associated specialties, affiliations and a list of published articles.
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46
Citations
433
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Recent Articles
1.
Willmott M, Finnigan W, Birmingham W, Derrington S, Heath R, Schnepel C, et al.
Nat Synth
. 2025 Feb;
4(2):156-166.
PMID: 39959249
Nucleosides functionalized at the 2'-position play a crucial role in therapeutics, serving as both small-molecule drugs and modifications in therapeutic oligonucleotides. However, the synthesis of these molecules often presents substantial...
2.
Williams S, Faurdal D, Jorgensen T, Back C, Rooms L, Hayes M, et al.
Microbiol Resour Announc
. 2025 Jan;
14(2):e0115824.
PMID: 39812635
Here, we report the resequencing, assembly, and annotation of two actinomycete genomes containing abyssomicin gene clusters. DSM 45791 with a circular chromosome of 11,681,598 bp and 4 circular plasmids (14,175-207,548...
3.
Chihomvu P, Ganesan A, Gibbons S, Woollard K, Hayes M
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201478
Phytochemicals have a long and successful history in drug discovery. With recent advancements in analytical techniques and methodologies, discovering bioactive leads from natural compounds has become easier. Computational techniques like...
4.
Mbatha S, Back C, Devine A, Mulliner H, Johns S, Lewin H, et al.
Chem Sci
. 2024 Aug;
PMID: 39144453
The abyssomicins are a structurally intriguing family of bioactive natural products that include compounds with potent antibacterial, antitumour and antiviral activities. The biosynthesis of the characteristic abyssomicin spirotetronate core occurs...
5.
Maschio L, Back C, Alnawah J, Bowen J, Johns S, Mbatha S, et al.
Chem Sci
. 2024 Jul;
15(29):11572-11583.
PMID: 39055018
The Diels-Alder reaction is one of the most effective methods for the synthesis of substituted cyclohexenes. The development of protein catalysts for this reaction remains a major priority, affording new...
6.
Devine A, Parnell A, Back C, Lees N, Johns S, Zulkepli A, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(3):e202213053.
PMID: 38516347
Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using...
7.
Romero E, Jones B, Hogg B, Rue Casamajo A, Hayes M, Flitsch S, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(31):16962-16993.
PMID: 38505660
No abstract available.
8.
Hogg B, Schnepel C, Finnigan J, Charnock S, Hayes M, Turner N
Angew Chem Int Ed Engl
. 2024 Mar;
63(21):e202402316.
PMID: 38494442
In the ever-growing demand for sustainable ways to produce high-value small molecules, biocatalysis has come to the forefront of greener routes to these chemicals. As such, the need to constantly...
9.
Petchey M, Ye Y, Spelling V, Finnigan J, Gittings S, Johansson M, et al.
J Am Chem Soc
. 2024 Feb;
146(7):5005-5010.
PMID: 38329236
Radical hydrofunctionalizations of electronically unbiased dienes are challenging to render regioselective, because the products are nearly identical in energy. Here, we report two engineered FMN-dependent "ene"-reductases (EREDs) that catalyze regiodivergent...
10.
Jurva U, Sandinge A, Baek J, Avanthay M, Thomson R, DCunha S, et al.
Drug Metab Dispos
. 2024 Jan;
52(3):242-251.
PMID: 38176735
Detailed structural characterization of small molecule metabolites is desirable during all stages of drug development, and often relies on the synthesis of metabolite standards. However, introducing structural changes into already...