Martin A Hayes
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Explore the profile of Martin A Hayes including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Jones B, Ross C, Foley G, Pozhydaieva N, Sharratt J, Kress N, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(18):e202314869.
PMID: 38163289
Selective, one-step C-H activation of fatty acids from biomass is an attractive concept in sustainable chemistry. Biocatalysis has shown promise for generating high-value hydroxy acids, but to date enzyme discovery...
12.
Menke M, Schneider P, Badenhorst C, Kunzendorf A, Heinz F, Dorr M, et al.
Angew Chem Int Ed Engl
. 2023 Nov;
62(51):e202313912.
PMID: 37917964
Enzyme-catalyzed late-stage functionalization (LSF), such as methylation of drug molecules and lead structures, enables direct access to more potent active pharmaceutical ingredients (API). S-adenosyl-l-methionine-dependent methyltransferases (MTs) can play a key...
13.
Rue Casamajo A, Yu Y, Schnepel C, Morrill C, Barker R, Levy C, et al.
J Am Chem Soc
. 2023 Oct;
145(40):22041-22046.
PMID: 37782882
Novel building blocks are in constant demand during the search for innovative bioactive small molecule therapeutics by enabling the construction of structure-activity-property-toxicology relationships. Complex chiral molecules containing multiple stereocenters are...
14.
Zorn K, Back C, Barringer R, Chadimova V, Manzo-Ruiz M, Mbatha S, et al.
Chembiochem
. 2023 Jun;
24(14):e202300382.
PMID: 37305956
Stereoselective carbon-carbon bond forming reactions are quintessential transformations in organic synthesis. One example is the Diels-Alder reaction, a [4+2] cycloaddition between a conjugated diene and a dienophile to form cyclohexenes....
15.
Devine A, Parnell A, Back C, Lees N, Johns S, Zulkepli A, et al.
Angew Chem Int Ed Engl
. 2022 Oct;
62(3):e202213053.
PMID: 36314667
Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using...
16.
Thomson R, DCunha S, Hayes M, Gillam E
Adv Pharmacol
. 2022 Aug;
95:195-252.
PMID: 35953156
Numerous steps in drug development, including the generation of authentic metabolites and late-stage functionalization of candidates, necessitate the modification of often complex molecules, such as natural products. While it can...
17.
Romero E, Johansson M, Cartwright J, Grogan G, Hayes M
Angew Chem Int Ed Engl
. 2022 Aug;
61(39):e202207831.
PMID: 35916874
H O -driven enzymes are of great interest for industrial biotransformations. Herein, we show for the first time that oxalate oxidase (OXO) is an efficient in situ source of H...
18.
Charlton S, Hayes M
ChemMedChem
. 2022 Apr;
17(12):e202200115.
PMID: 35385205
C-H oxyfunctionalisation remains a distinct challenge for synthetic organic chemists. Oxygenases and peroxygenases (grouped here as "oxygenating biocatalysts") catalyse the oxidation of a substrate with molecular oxygen or hydrogen peroxide...
19.
Sardana M, Muhlfenzl K, Wenker S, Akesson C, Hayes M, Elmore C, et al.
J Labelled Comp Radiopharm
. 2022 Jan;
65(4):86-100.
PMID: 34997781
Cyclopropanes are commonly employed structural moieties in drug design since their incorporation is often associated with increased target affinity, improved metabolic stability, and increased rigidity to access bioactive conformations. Robust...
20.
Weis E, Hayes M, Johansson M, Martin-Matute B
iScience
. 2021 May;
24(5):102467.
PMID: 34027322
Late-stage functionalization (LSF) has over the past years emerged as a powerful approach in the drug discovery process. At its best, it allows for rapid access to new analogues from...