Xue-Qing Li
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Explore the profile of Xue-Qing Li including associated specialties, affiliations and a list of published articles.
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Articles
44
Citations
645
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Recent Articles
1.
James A, Lanshoeft C, Steeno G, Spracklin D, You Z, Sharma R, et al.
Drug Metab Dispos
. 2025 Mar;
53(3):100041.
PMID: 40048992
The mixed matrix method (MmM) is a widely used approach by the pharmaceutical industry for early assessment of whether exposures to major human circulating metabolites, of traditional small-molecule drugs, are...
2.
Li X, Zeng L, Li Y, Lv A, Dong R, Qi J, et al.
Int J Biol Macromol
. 2025 Mar;
306(Pt 3):141614.
PMID: 40032103
The study investigated the impact of varying concentrations of (E,E)-2,4-decadienal (DDE; 0, 9, 27, 54, and 81 μg/mL) on the stability of gelatin emulsions prepared via a low-energy stirring emulsification...
3.
Karlsson I, Ekdahl A, Etchingham-Coll H, Li X, Ericsson C, Ahlqvist M, et al.
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39940909
Xenobiotics, including drugs, undergo metabolism to facilitate detoxification and excretion. Predicting a compound's metabolic fate before clinical trials is crucial for efficacy and safety. The existing methods rely on in...
4.
Wen Y, Liu C, Yuan Q, Wang R, Li X, Yuan D, et al.
Zhongguo Zhong Yao Za Zhi
. 2025 Jan;
49(23):6490-6499.
PMID: 39805795
In this study, the chemical components of Panacis Japonici Rhizoma extract and absorbed components in rats were identified by ultra-high performance liquid chromatography-quadrupole exactive orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap-MS). The separation...
5.
Yao X, Dong R, Li Y, Lv A, Zeng L, Li X, et al.
Int J Biol Macromol
. 2024 Nov;
282(Pt 2):136979.
PMID: 39490473
The effects of pH-shifting treatments (pH 3, 5, 7, 9, and 11) on the stability of gelatin emulsions made by low-energy stirring were investigated. pH-shifting treatments significantly enhanced the ESI...
6.
Li X, Lindmark B, Amilon C, Samuelsson K, Weidolf L, Nelander K, et al.
Pharmacol Res Perspect
. 2024 Oct;
12(5):e70029.
PMID: 39400479
In this study, the mass balance, pharmacokinetics (PK) and metabolism of atuliflapon, a novel 5-lipoxygenase-activating protein inhibitor, were investigated in healthy male subjects. A single oral dose of 200 mg...
7.
Pan E, Xin Y, Li X, Wu X, Tan X, Dong J
Fish Physiol Biochem
. 2023 Aug;
49(5):895-910.
PMID: 37542703
The aim of this study was to investigate the splenic tissue damage of environmental biological drug avermectin to freshwater cultured carp and to evaluate the effect of silybin on the...
8.
Li X, Elebring M, Dahlen A, Weidolf L
Drug Metab Dispos
. 2023 Jul;
51(10):1350-1361.
PMID: 37429729
AZD8233, a liver-targeting antisense oligonucleotide (ASO), inhibits subtilisin/kexin type 9 protein synthesis. It is a phosphorothioated 3-10-3 gapmer with a central DNA sequence flanked by constrained 2'--ethyl 2',4'-bridged nucleic acid...
9.
Lindmark B, Li X, Bhattacharya C, Housler G, Heijer M, Bragg R, et al.
Drug Metab Dispos
. 2023 Jul;
51(8):995-1004.
PMID: 37407094
An absorption, distribution, metabolism, and excretion study was performed to determine the basic pharmacokinetic parameters, mass balance, and metabolite profiles of balcinrenone, a mineralocorticoid receptor modulator, in humans. This open-label,...
10.
Jurva U, Weidolf L, Sandinge A, Leandersson C, Ekdahl A, Li X, et al.
Drug Metab Dispos
. 2023 Jan;
51(4):464-479.
PMID: 36653117
We report herein an in-depth analysis of the metabolism of the novel myeloperoxidase inhibitor AZD4831 (()-1-(2-(1-aminoethyl)-4-chlorobenzyl)-2-thioxo-2,3-dihydro-1H-pyrrolo[3,2-]pyrimidin-4(5)-one) in animals and human. Quantitative and qualitative metabolite profiling were performed on samples collected...