Paul R Race
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Explore the profile of Paul R Race including associated specialties, affiliations and a list of published articles.
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Citations
639
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Recent Articles
1.
Williams S, Faurdal D, Jorgensen T, Back C, Rooms L, Hayes M, et al.
Microbiol Resour Announc
. 2025 Jan;
14(2):e0115824.
PMID: 39812635
Here, we report the resequencing, assembly, and annotation of two actinomycete genomes containing abyssomicin gene clusters. DSM 45791 with a circular chromosome of 11,681,598 bp and 4 circular plasmids (14,175-207,548...
2.
Maddock R, Marsh C, Johns S, Rooms L, Duke P, van der Kamp M, et al.
Extremophiles
. 2024 Aug;
28(3):42.
PMID: 39215799
Methanogenic archaea are chemolithotrophic prokaryotes that can reduce carbon dioxide with hydrogen gas to form methane. These microorganisms make a significant contribution to the global carbon cycle, with methanogenic archaea...
3.
Mbatha S, Back C, Devine A, Mulliner H, Johns S, Lewin H, et al.
Chem Sci
. 2024 Aug;
PMID: 39144453
The abyssomicins are a structurally intriguing family of bioactive natural products that include compounds with potent antibacterial, antitumour and antiviral activities. The biosynthesis of the characteristic abyssomicin spirotetronate core occurs...
4.
Williams S, Varliero G, Lurgi M, Stach J, Race P, Curnow P
Microbiology (Reading)
. 2024 Jul;
170(7).
PMID: 39073401
Sponges (phylum Porifera) harbour specific microbial communities that drive the ecology and evolution of the host. Understanding the structure and dynamics of these communities is emerging as a primary focus...
5.
Maschio L, Back C, Alnawah J, Bowen J, Johns S, Mbatha S, et al.
Chem Sci
. 2024 Jul;
15(29):11572-11583.
PMID: 39055018
The Diels-Alder reaction is one of the most effective methods for the synthesis of substituted cyclohexenes. The development of protein catalysts for this reaction remains a major priority, affording new...
6.
Devine A, Parnell A, Back C, Lees N, Johns S, Zulkepli A, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(3):e202213053.
PMID: 38516347
Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using...
7.
Winter A, Khanizeman R, Barker-Mountford A, Devine A, Wang L, Song Z, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(47):e202312514.
PMID: 38515435
Mupirocin is a clinically important antibiotic produced by a -AT Type I polyketide synthase (PKS) in . The major bioactive metabolite, pseudomonic acid A (PA-A), is assembled on a tetrasubstituted...
8.
Winter A, Rowe M, Weir A, Akter N, Mbatha S, Walker P, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
134(50):e202212393.
PMID: 38505625
Mupirocin is a clinically important antibiotic produced by NCIMB 10586 that is assembled by a complex -AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid...
9.
Winter A, Khanizeman R, Barker-Mountford A, Devine A, Wang L, Song Z, et al.
Angew Chem Int Ed Engl
. 2023 Sep;
62(47):e202312514.
PMID: 37768840
Mupirocin is a clinically important antibiotic produced by a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens. The major bioactive metabolite, pseudomonic acid A (PA-A), is assembled on a...
10.
Hutchins G, Noble C, Bunzel H, Williams C, Dubiel P, Yadav S, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(31):e2306046120.
PMID: 37487099
The electron-conducting circuitry of life represents an as-yet untapped resource of exquisite, nanoscale biomolecular engineering. Here, we report the characterization and structure of a de novo diheme "maquette" protein, 4D2,...