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Marta Ruiz-Santaquiteria

Explore the profile of Marta Ruiz-Santaquiteria including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 53
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Maria-Jose Camarasa
Federico Gago
Sonsoles Velazquez
Antonio Jimenez-Ruiz
Pedro A Sanchez-Murcia
Miguel A Toro
Hector de Lucio
Kilian Jesus Gutierrez
Sonia de Castro
Ana Gamo
Published In
Eur J Med Chem
Chembiochem
Chemistry
ACS Infect Dis
Affiliations
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Recent Articles
1.
Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors
Ruiz-Santaquiteria M, Illescas B, Abdelnabi R, Boonen A, Mills A, Marti-Mari O, et al.
Chemistry . 2021 Apr; 27(41):10700-10710. PMID: 33851758
Unprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and...
2.
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase
Revuelto A, Ruiz-Santaquiteria M, de Lucio H, Gamo A, Carriles A, Gutierrez K, et al.
ACS Infect Dis . 2019 Apr; 5(6):873-891. PMID: 30983322
Disruption of protein-protein interactions of essential oligomeric enzymes by small molecules represents a significant challenge. We recently reported some linear and cyclic peptides derived from an α-helical region present in...
3.
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability
Ruiz-Santaquiteria M, de Castro S, Toro M, de Lucio H, Gutierrez K, Sanchez-Murcia P, et al.
Eur J Med Chem . 2018 Mar; 149:238-247. PMID: 29501944
Trypanothione reductase (TryR) is a well-established target in the search for novel antitrypanosomal and antileishmanial agents. We have previously identified linear and lactam-bridged 13-residue peptides derived from an α-helical region...
4.
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides
de Lucio H, Gamo A, Ruiz-Santaquiteria M, de Castro S, Sanchez-Murcia P, Toro M, et al.
Eur J Med Chem . 2017 Oct; 140:615-623. PMID: 29017116
The objective of the current study was to enhance the proteolytic stability of peptide-based inhibitors that target critical protein-protein interactions at the dimerization interface of Leishmania infantum trypanothione reductase (Li-TryR)...
5.
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity
Ruiz-Santaquiteria M, Sanchez-Murcia P, Toro M, de Lucio H, Gutierrez K, de Castro S, et al.
Eur J Med Chem . 2017 Apr; 135:49-59. PMID: 28431354
A series of 9-mer and 13-mer amide-bridged cyclic peptides derived from the linear prototype Ac-PKIIQSVGIS-Nle-K-Nle-NH (Toro et al. ChemBioChem2013) has been designed and synthesized by introduction of the lactam between...
6.
Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides
Toro M, Sanchez-Murcia P, Moreno D, Ruiz-Santaquiteria M, Alzate J, Negri A, et al.
Chembiochem . 2013 Jun; 14(10):1212-7. PMID: 23744811
Binding at the interface: We tested the inhibitory activity of a set of peptide sequences derived from an α-helix of the dimeric trypanothione reductase from Leishmania infantum. Replacement of a...