Marta Larrayoz
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Explore the profile of Marta Larrayoz including associated specialties, affiliations and a list of published articles.
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21
Citations
549
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Recent Articles
11.
Garcia-Barchino M, Sarasquete M, Panizo C, Morscio J, Martinez A, Alcoceba M, et al.
J Pathol
. 2018 Feb;
245(1):61-73.
PMID: 29464716
The increased risk of Richter transformation (RT) in patients with chronic lymphocytic leukaemia (CLL) due to Epstein-Barr virus (EBV) reactivation during immunosuppressive therapy with fludarabine other targeted agents remains controversial....
12.
Johnston H, Carter M, Larrayoz M, Clarke J, Garbis S, Oscier D, et al.
Mol Cell Proteomics
. 2018 Jan;
17(4):776-791.
PMID: 29367434
Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell cancer exhibiting a wide spectrum of disease courses and treatment responses. Molecular characterization of RNA and DNA from CLL cases has led...
13.
Blunt M, Koehrer S, Dobson R, Larrayoz M, Wilmore S, Hayman A, et al.
Clin Cancer Res
. 2016 Oct;
23(9):2313-2324.
PMID: 27697994
B-cell receptor (BCR)-associated kinase inhibitors, such as ibrutinib, have revolutionized the treatment of chronic lymphocytic leukemia (CLL). However, these agents are not curative, and resistance is already emerging in a...
14.
DAvola A, Drennan S, Tracy I, Henderson I, Chiecchio L, Larrayoz M, et al.
Blood
. 2016 Jun;
128(6):816-26.
PMID: 27301861
Chronic lymphocytic leukemia (CLL) with unmutated (U-CLL) or mutated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) displays different states of anergy, indicated by reduced surface immunoglobulin M (sIgM) levels and...
15.
Sutton L, Young E, Baliakas P, Hadzidimitriou A, Moysiadis T, Plevova K, et al.
Haematologica
. 2016 May;
101(8):959-67.
PMID: 27198719
We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated stereotyped B-cell receptor immunoglobulins in the largest cohort (n=565) studied...
16.
Aguilar-Hernandez M, Blunt M, Dobson R, Yeomans A, Thirdborough S, Larrayoz M, et al.
Blood
. 2016 Mar;
127(24):3015-25.
PMID: 27002119
Kinase inhibitors targeting the B-cell receptor (BCR) are now prominent in the treatment of chronic lymphocytic leukemia (CLL). We have focused here on interleukin 4 (IL-4), a cytokine that protects...
17.
Azpilikueta A, Agorreta J, Labiano S, Perez-Gracia J, Sanchez-Paulete A, Aznar M, et al.
J Thorac Oncol
. 2016 Feb;
11(4):524-36.
PMID: 26845193
Introduction: Anti-programmed cell death 1 (anti-PD-1) and anti-programmed cell death ligand 1 (PD-L1) antagonist monoclonal antibodies (mAbs) against metastatic non-small cell lung cancer with special efficacy in patients with squamous...
18.
Blunt M, Carter M, Larrayoz M, Smith L, Aguilar-Hernandez M, Cox K, et al.
Blood
. 2015 May;
125(26):4032-41.
PMID: 25957390
Current treatment strategies for chronic lymphocytic leukemia (CLL) involve a combination of conventional chemotherapeutics, monoclonal antibodies, and targeted signaling inhibitors. However, CLL remains largely incurable, with drug resistance and treatment...
19.
Grbesa I, Pajares M, Martinez-Terroba E, Agorreta J, Mikecin A, Larrayoz M, et al.
PLoS One
. 2015 Apr;
10(4):e0124670.
PMID: 25915617
Background: Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases...
20.
Agorreta J, Hu J, Liu D, Delia D, Turley H, Ferguson D, et al.
Mol Cancer Res
. 2014 Feb;
12(5):660-9.
PMID: 24567527
Unlabelled: The TNF receptor-associated protein 1 (TRAP1) is a mitochondrial HSP that has been related to drug resistance and protection from apoptosis in colorectal and prostate cancer. Here, the effect...