Marlene van den Berg
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Explore the profile of Marlene van den Berg including associated specialties, affiliations and a list of published articles.
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24
Citations
671
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Recent Articles
1.
Meurs A, Ndoj K, van den Berg M, Marinkovic G, Tantucci M, Veenendaal T, et al.
Cardiovasc Res
. 2024 Jun;
120(11):1253-1264.
PMID: 38833612
Aims: Apolipoprotein B (APOB)-containing very LDL (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and circulating lipid levels. Impairment of any of the aforementioned processes...
2.
van Wouw S, van den Berg M, El Ouraoui M, Meurs A, Kingma J, Ottenhoff R, et al.
J Lipid Res
. 2023 Jan;
64(2):100325.
PMID: 36592658
Lysoplasmalogens are a class of vinyl ether bioactive lipids that have a central role in plasmalogen metabolism and membrane fluidity. The liver X receptor (LXR) transcription factors are important determinants...
3.
Avagliano Trezza R, Punt A, Mientjes E, van den Berg M, Zampeta F, de Graaf I, et al.
Sci Rep
. 2021 Feb;
11(1):3007.
PMID: 33542309
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by brain-specific loss of UBE3A, an E3 ubiquitin protein ligase. A substantial number of possible ubiquitination targets of UBE3A have been...
4.
Tan J, van der Stoel M, van den Berg M, van Loon N, Moeton M, Scholl E, et al.
Cell Rep
. 2020 Aug;
32(5):107944.
PMID: 32755570
The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is...
5.
Loregger A, Raaben M, Nieuwenhuis J, Tan J, Jae L, van den Hengel L, et al.
Nat Commun
. 2020 Mar;
11(1):1128.
PMID: 32111832
The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify the SREBP Regulating Gene (SPRING/C12ORF49) as a determinant of the SREBP...
6.
Avagliano Trezza R, Sonzogni M, Bossuyt S, Zampeta F, Punt A, van den Berg M, et al.
Nat Neurosci
. 2019 Jun;
22(8):1235-1247.
PMID: 31235931
Mutations affecting the gene encoding the ubiquitin ligase UBE3A cause Angelman syndrome. Although most studies focus on the synaptic function of UBE3A, we show that UBE3A is highly enriched in...
7.
Tan J, Cook E, van den Berg M, Scheij S, Zelcer N, Loregger A
Atherosclerosis
. 2019 Jan;
281:137-142.
PMID: 30658189
Background And Aims: Cholesterol is an essential lipid for cellular function and membrane integrity, and hence its cellular levels and distribution must be tightly regulated. Biosynthesis of cholesterol is ramped...
8.
Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, et al.
Arterioscler Thromb Vasc Biol
. 2017 Sep;
37(11):2064-2074.
PMID: 28882874
Objective: The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), a rate-limiting enzyme in this pathway and the...
9.
Hakonen J, Sorrentino V, Avagliano Trezza R, de Wissel M, van den Berg M, Bleijlevens B, et al.
Hum Mol Genet
. 2017 Mar;
26(11):2034-2041.
PMID: 28335037
Charcot-Marie-Tooth (CMT) disease type 2 is a genetically heterogeneous group of inherited neuropathies characterized by motor and sensory deficits as a result of peripheral axonal degeneration. We recently reported a...
10.
Williams C, van den Berg M, Stanley W, Wilmanns M, Distel B
Sci Rep
. 2013 Jul;
3:2212.
PMID: 23896733
The ubiquitin-conjugating enzyme Pex4p together with its binding partner, the peroxisomal membrane protein Pex22p, co-ordinates cysteine-dependent ubiquitination of the cycling receptor protein Pex5p. Unusually for an ubiquitin-conjugating enzyme, Saccharomyces cerevisiae...