Mark T Bilodeau
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Explore the profile of Mark T Bilodeau including associated specialties, affiliations and a list of published articles.
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52
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Recent Articles
11.
Stachel S, Sanders J, Henze D, Rudd M, Su H, Li Y, et al.
J Med Chem
. 2014 Jun;
57(13):5800-16.
PMID: 24914455
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from...
12.
Yang Z, Shu Y, Ma L, Wittmann M, Ray W, Seager M, et al.
ACS Med Chem Lett
. 2014 Jun;
5(5):604-8.
PMID: 24900888
Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an original approach to treat the cognitive decline in patients with Alzheimer's disease. A series of naphthyl-fused 5-membered...
13.
Kuduk S, Chang R, Greshock T, Ray W, Ma L, Wittmann M, et al.
ACS Med Chem Lett
. 2014 Jun;
3(12):1070-4.
PMID: 24900430
Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined...
14.
Kuduk S, Chang R, Di Marco C, Ray W, Ma L, Wittmann M, et al.
ACS Med Chem Lett
. 2014 Jun;
1(6):263-7.
PMID: 24900206
Positive allosteric modulation of the M1 muscarinic receptor represents an approach to treat the cognitive decline in patients with Alzheimer's disease. Replacement of a quinolone ring system in a quinolone...
15.
Kuduk S, Di Marco C, Saffold J, Ray W, Ma L, Wittmann M, et al.
Bioorg Med Chem Lett
. 2014 Feb;
24(5):1417-20.
PMID: 24485781
A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp...
16.
Nanda K, Henze D, Della Penna K, Desai R, Leitl M, Lemaire W, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(4):1218-21.
PMID: 24461289
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
17.
Pavri B, Greenberg H, Kraft W, Lazarus N, Lynch J, Salata J, et al.
Circ Arrhythm Electrophysiol
. 2012 Oct;
5(6):1193-201.
PMID: 23060423
Background: We evaluated the viability of I(Kur) as a target for maintenance of sinus rhythm in patients with a history of atrial fibrillation through the testing of MK-0448, a novel...
18.
Kuduk S, Di Marco C, Bodmer-Narkevitch V, Cook S, Cato M, Jovanovska A, et al.
ACS Chem Neurosci
. 2012 Jul;
1(1):19-24.
PMID: 22778804
The synthesis, structure-activity relationship (SAR), and pharmacological evaluation of analogs of the acid-sensing ion channel (ASIC) inhibitor A-317567 are reported. It was found that the compound with an acetylenic linkage...
19.
Kuduk S, Chang R, Di Marco C, Pitts D, Greshock T, Ma L, et al.
J Med Chem
. 2011 Jun;
54(13):4773-80.
PMID: 21682298
One approach to ameliorate the cognitive decline in Alzheimer's disease (AD) has been to restore neuronal signaling from the basal forebrain cholinergic system via the activation of the M(1) muscarinic...
20.
Kuduk S, Chang R, Di Marco C, DiPardo R, Cook S, Cato M, et al.
Bioorg Med Chem Lett
. 2011 Jun;
21(14):4255-8.
PMID: 21669528
A series of benzothiophene methyl amines were examined in an effort to identify non-amidine chemotypes with reduced polypharmacology from existing leads with the goal of finding potent ASIC3 channel blockers...