Identification of a Methoxynaphthalene Scaffold As a Core Replacement in Quinolizidinone Amide M(1) Positive Allosteric Modulators

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2014 Feb 4

PMID 24485781

Citations 6

Authors

Scott D Kuduk

Christina N Di Marco

Jonathan R Saffold

William J Ray

Lei Ma

Marion Wittmann

Kenneth A Koeplinger

Charles D Thompson

George D Hartman

Mark T Bilodeau

Douglas C Beshore

Affiliations

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Abstract

A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp issues present in the aforementioned quinolizidinone amide series.

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