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Mark S Alber

Explore the profile of Mark S Alber including associated specialties, affiliations and a list of published articles. Areas
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Articles 34
Citations 742
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Recent Articles
1.
Kim O, Nevzorova T, Mordakhanova E, Ponomareva A, Andrianova I, Le Minh G, et al.
Haematologica . 2019 Feb; 104(9):1866-1878. PMID: 30792211
Platelets play a key role in the formation of hemostatic clots and obstructive thrombi as well as in other biological processes. In response to physiological stimulants, including thrombin, platelets change...
2.
Kim O, Litvinov R, Alber M, Weisel J
Nat Commun . 2017 Nov; 8(1):1274. PMID: 29097692
Blood clot contraction plays an important role in prevention of bleeding and in thrombotic disorders. Here, we unveil and quantify the structural mechanisms of clot contraction at the level of...
3.
Hook P, Litvinov R, Kim O, Xu S, Xu Z, Bennett J, et al.
Sci Rep . 2017 Oct; 7(1):13001. PMID: 29021578
The formation of platelet thrombi is determined by the integrin αIIbβ3-mediated interactions of platelets with fibrinogen and fibrin. Blood clotting in vivo is catalyzed by thrombin, which simultaneously induces fibrinogen...
4.
Hook P, Brito-Robinson T, Kim O, Narciso C, Goodson H, Weisel J, et al.
Biomed Opt Express . 2017 Sep; 8(8):3671-3686. PMID: 28856043
A technological revolution in both light and electron microscopy imaging now allows unprecedented views of clotting, especially in animal models of hemostasis and thrombosis. However, our understanding of three-dimensional high-resolution...
5.
Duan A, Jonasson E, Alberico E, Li C, Scripture J, Miller R, et al.
J Mol Biol . 2017 Mar; 429(9):1424-1438. PMID: 28322917
Tau is a multifaceted neuronal protein that stabilizes microtubules (MTs), but the mechanism of this activity remains poorly understood. Questions include whether Tau binds MTs laterally or longitudinally and whether...
6.
Chen J, Alber M, Chen D
IEEE Trans Med Imaging . 2016 Apr; 35(9):2074-84. PMID: 27046892
Cell segmentation and motion tracking in time-lapse images are fundamental problems in computer vision, and are also crucial for various biomedical studies. Myxococcus xanthus is a type of rod-like cells...
7.
Kim O, Liang X, Litvinov R, Weisel J, Alber M, Purohit P
Biomech Model Mechanobiol . 2015 May; 15(1):213-228. PMID: 25982442
The rheological properties of fibrin networks have been of long-standing interest. As such there is a wealth of studies of their shear and tensile responses, but their compressive behavior remains...
8.
Tierra G, Pavissich J, Nerenberg R, Xu Z, Alber M
J R Soc Interface . 2015 Mar; 12(106). PMID: 25808342
A novel biofilm model is described which systemically couples bacteria, extracellular polymeric substances (EPS) and solvent phases in biofilm. This enables the study of contributions of rheology of individual phases...
9.
Chen J, Harvey C, Alber M, Chen D
Med Image Comput Comput Assist Interv . 2014 Dec; 17(Pt 2):113-20. PMID: 25485369
Tracking the motion of Myxococcus xanthus is a crucial step for fundamental bacteria studies. Large number of bacterial cells involved, limited image resolution, and various cell behaviors (e.g., division) make...
10.
Chen Y, Corey S, Kim O, Alber M
Adv Exp Med Biol . 2014 Dec; 844:85-98. PMID: 25480638
Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss. However, hemostatic events can...