John W Weisel
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Explore the profile of John W Weisel including associated specialties, affiliations and a list of published articles.
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204
Citations
5751
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Recent Articles
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Weisel J, Litvinov R
Blood
. 2025 Feb;
PMID: 40019439
Thrombus structure and composition are the main determinants of the severity, course, and outcomes of thrombosis. Detailed thrombus morphology has become available due to mechanical thrombectomy, which allows extraction of...
3.
Kliuchnikov E, Peshkova A, Vo M, Marx K, Litvinov R, Weisel J, et al.
NPJ Biol Phys Mech
. 2025 Feb;
2(1):6.
PMID: 40012560
Mechanisms of blood clot contraction - platelet-driven fibrin network remodeling, are not fully understood. We developed a detailed computational model of fibrin network with activated platelets, whose clot contraction rate...
4.
Andrianova I, Hayes V, Litvinov R, Nagaswami C, Arepally G, Cines D, et al.
J Thromb Haemost
. 2025 Feb;
PMID: 39933652
Background: Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder associated with thrombosis developing in response to anticoagulation with heparin. Monocytes targeted by HIT antibodies contribute to the prothrombotic state, but structural...
5.
Peshkova A, Brysgel T, Mody P, Nong J, Wang Z, Myerson J, et al.
Bioconjug Chem
. 2025 Jan;
36(2):263-275.
PMID: 39869932
Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the pharmacokinetics and pharmacodynamics of a protein cargo. Affinity targeting of Factor IX (FIX) to the...
6.
Yu X, Zhao Q, Yaman M, Emly S, Lee J, Su H, et al.
bioRxiv
. 2024 Nov;
PMID: 39605542
Venous thrombosis is a well-known complication of sex hormone therapy, with onset typically within weeks to months after initiation. Worldwide, more than 100 million pre-menopausal women use combined oral contraceptives,...
7.
Ramanujam R, Maksudov F, Risman R, Litvinov R, Weisel J, Bassani J, et al.
Acta Biomater
. 2024 Oct;
190:329-343.
PMID: 39395704
Embolization is a leading cause of mortality, yet we know little about clot rupture mechanics. Fibrin provides the main structural and mechanical stability to blood clots. Previous studies have shown...
8.
Peshkova A, Saliakhutdinova S, Sounbuli K, Selivanova Y, Andrianova I, Khabirova A, et al.
Thromb Res
. 2024 Jul;
241:109092.
PMID: 39024901
Background: Leukocyte-platelet aggregates comprise a pathogenic link between hemostasis and immunity, but the prerequisites and mechanisms of their formation remain not understood. Aims: To quantify the formation, composition, and morphology...
9.
Ramanujam R, Garyfallogiannis K, Litvinov R, Bassani J, Weisel J, Purohit P, et al.
Soft Matter
. 2024 Apr;
20(21):4184-4196.
PMID: 38686609
Intravascular blood clots are subject to hydrodynamic shear and other forces that cause clot deformation and rupture (embolization). A portion of the ruptured clot can block blood flow in downstream...
10.
Sidonio Jr R, Weisel J, Stafford D
Haemophilia
. 2024 Apr;
30 Suppl 3:70-77.
PMID: 38575518
Despite rapid technological advancement in factor and nonfactor products in the prevention and treatment of bleeding in haemophilia patients, it is imperative that we acknowledge gaps in our understanding of...