Oleg V Kim
Overview
Explore the profile of Oleg V Kim including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
309
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Recent Articles
1.
Megakaryocyte-induced contraction of plasma clots: cellular mechanisms and structural mechanobiology
Kim O, Litvinov R, Gagne A, French D, Brass L, Weisel J
Blood
. 2023 Nov;
143(6):548-560.
PMID: 37944157
Nonmuscle cell contractility is an essential feature underlying diverse cellular processes such as motility, morphogenesis, division and genome replication, intracellular transport, and secretion. Blood clot contraction is a well-studied process...
2.
Michael C, Pancaldi F, Britton S, Kim O, Peshkova A, Vo K, et al.
Commun Biol
. 2023 Aug;
6(1):869.
PMID: 37620422
While blood clot formation has been relatively well studied, little is known about the mechanisms underlying the subsequent structural and mechanical clot remodeling called contraction or retraction. Impairment of the...
3.
Kim O, Litvinov R, Mordakhanova E, Bi E, Vagin O, Weisel J
iScience
. 2022 Jul;
25(7):104654.
PMID: 35832887
Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We...
4.
Pancaldi F, Kim O, Weisel J, Alber M, Xu Z
Curr Opin Biomed Eng
. 2022 Apr;
22.
PMID: 35386550
Fibrin deformation and interaction of fibrin with other blood components play critical roles in hemostasis and thrombosis. In this review, computational and mathematical biomechanical models of fibrin network deformation and...
5.
Fong K, Molnar K, Agard N, Litvinov R, Kim O, Wells J, et al.
Blood Adv
. 2021 Sep;
5(23):4901-4909.
PMID: 34570183
Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here we show that clot contraction is...
6.
Fong K, Ahmed I, Mravic M, Jo H, Kim O, Litvinov R, et al.
Biochemistry
. 2021 May;
60(21):1722-1730.
PMID: 34010565
The fluorescent reporters commonly used to visualize proteins can perturb both protein structure and function. Recently, we found that 4-cyanotryptophan (4CN-Trp), a blue fluorescent amino acid, is suitable for one-photon...
7.
8.
Kim O, Nevzorova T, Mordakhanova E, Ponomareva A, Andrianova I, Le Minh G, et al.
Haematologica
. 2019 Feb;
104(9):1866-1878.
PMID: 30792211
Platelets play a key role in the formation of hemostatic clots and obstructive thrombi as well as in other biological processes. In response to physiological stimulants, including thrombin, platelets change...
9.
Xu S, Xu Z, Kim O, Litvinov R, Weisel J, Alber M
J R Soc Interface
. 2017 Nov;
14(136).
PMID: 29142014
Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is characterized by formation of obstructive intravascular clots (thrombi) and their mechanical breakage (embolization). A novel two-dimensional multi-phase computational...
10.
Kim O, Litvinov R, Alber M, Weisel J
Nat Commun
. 2017 Nov;
8(1):1274.
PMID: 29097692
Blood clot contraction plays an important role in prevention of bleeding and in thrombotic disorders. Here, we unveil and quantify the structural mechanisms of clot contraction at the level of...