Mark R Philips
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Explore the profile of Mark R Philips including associated specialties, affiliations and a list of published articles.
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90
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4391
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Recent Articles
1.
Kochen Rossi J, Nuevo-Tapioles C, OKeefe R, Hunkeler M, Schmoker A, Fissore-OLeary M, et al.
Cell Rep
. 2024 Dec;
44(1):115087.
PMID: 39705142
Transcripts of the KRAS locus are alternatively spliced to generate two proteins, KRAS4A and KRAS4B, which differ in their membrane-targeting sequences. These splice variants have been conserved for more than...
2.
Ren J, Xing B, Lv K, OKeefe R, Wu M, Wang R, et al.
J Clin Invest
. 2023 Jun;
133(12).
PMID: 37317963
RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their...
3.
Kochen Rossi J, Nuevo-Tapioles C, Philips M
Biochem Soc Trans
. 2023 May;
51(3):1191-1199.
PMID: 37222266
RAS proteins are small GTPases that transduce signals from membrane receptors to signaling pathways that regulate growth and differentiation. Four RAS proteins are encoded by three genes - HRAS, KRAS,...
4.
Garcia-Espana A, Philips M
Oncogene
. 2023 Apr;
42(21):1741-1750.
PMID: 37031342
KRAS, HRAS and NRAS proto-oncogenes belong to a family of 40 highly homologous genes, which in turn are a subset of a superfamily of >160 genes encoding small GTPases. RAS...
5.
Simanshu D, Philips M, Hancock J
Mol Cell
. 2023 Mar;
83(8):1210-1215.
PMID: 36990093
One of the open questions in RAS biology is the existence of RAS dimers and their role in RAF dimerization and activation. The idea of RAS dimers arose from the...
6.
Garcia-Espana A, Philips M
Res Sq
. 2023 Jan;
PMID: 36711820
KRAS, HRAS and NRAS oncogenes belong to a family of 40 highly homologous genes, which in turn are a subset of a superfamily of >160 genes encoding small GTPases. RAS...
7.
Nuevo-Tapioles C, Philips M
Front Cell Dev Biol
. 2022 Nov;
10:1033348.
PMID: 36393833
The three mammalian genes (, and ) encode four proteins that play central roles in cancer biology. Among them, is mutated more frequently in human cancer than any other oncogene....
8.
Parker S, Encarnacion-Rosado J, Hollinshead K, Hollinshead D, Ash L, Rossi J, et al.
Nat Commun
. 2021 Aug;
12(1):4905.
PMID: 34385458
α-ketoglutarate (KG), also referred to as 2-oxoglutarate, is a key intermediate of cellular metabolism with pleiotropic functions. Cell-permeable esterified analogs are widely used to study how KG fuels bioenergetic and...
9.
Campbell S, Philips M
Curr Opin Struct Biol
. 2021 Aug;
71:180-192.
PMID: 34365229
Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS proteins integrate signals from a wide array of receptors and initiate downstream signaling through pathways that control...
10.
Ahearn I, Court H, Siddiqui F, Abankwa D, Philips M
Life Sci Alliance
. 2021 Feb;
4(5).
PMID: 33579760
Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the C-terminus of CaaX proteins, including RAS. Although all four RAS proteins are substrates for ICMT, each...