Mark Orcholski
Overview
Explore the profile of Mark Orcholski including associated specialties, affiliations and a list of published articles.
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14
Citations
191
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Recent Articles
1.
Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou E, Auer N, et al.
Eur Respir J
. 2023 Apr;
61(6).
PMID: 37024132
Introduction: Pulmonary arterial hypertension (PAH) is characterised by loss of microvessels. The Wnt pathways control pulmonary angiogenesis but their role in PAH is incompletely understood. We hypothesised that Wnt activation...
2.
De Jong H, Dewey F, Cordero P, Victorio R, Kirillova A, Huang Y, et al.
Circ Genom Precis Med
. 2022 Jun;
15(4):e003563.
PMID: 35671065
Background: The study of hypertrophic cardiomyopathy (HCM) can yield insight into the mechanisms underlying the complex trait of cardiac hypertrophy. To date, most genetic variants associated with HCM have been...
3.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, et al.
JACC Basic Transl Sci
. 2022 May;
7(4):384-403.
PMID: 35540097
The authors show that increased poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with...
4.
Wu W, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, et al.
Thorax
. 2021 Jul;
77(3):247-258.
PMID: 34226205
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are even worse when IPF results in...
5.
Grobs Y, Awada C, Lemay S, Romanet C, Bourgeois A, Toro V, et al.
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33805714
Trifluoperazine (TFP), an antipsychotic drug approved by the Food and Drug Administration, has been show to exhibit anti-cancer effects. Pulmonary arterial hypertension (PAH) is a devastating disease characterized by a...
6.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, et al.
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33803922
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by a sustained elevation of pulmonary artery (PA) pressure, right ventricular failure, and premature death. Enhanced proliferation and resistance to apoptosis...
7.
Vitry G, Paulin R, Grobs Y, Lampron M, Shimauchi T, Lemay S, et al.
Am J Respir Crit Care Med
. 2020 Oct;
203(5):614-627.
PMID: 33021405
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by abnormally elevated pulmonary pressures and right ventricular failure. Excessive proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells...
8.
Takahashi J, Orcholski M, Yuan K, De Jesus Perez V
FEBS Lett
. 2016 Jan;
590(1):101-9.
PMID: 26787464
Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary arterial smooth muscle cells (PASMCs) growth, partially in response to PDGF-BB but whether this is dependent on β-catenin (βC) activation is...
9.
Brunner N, Zamanian R, Ikeno F, Mitsutake Y, Connolly A, Shuffle E, et al.
Comp Med
. 2015 Jul;
65(3):217-24.
PMID: 26141446
Pulmonary arterial hypertension (PAH) is a devastating disorder characterized by progressive elevation of the pulmonary pressures that, in the absence of therapy, results in chronic right-heart failure and premature death....
10.
Helenius M, Vattulainen S, Orcholski M, Aho J, Komulainen A, Taimen P, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Mar;
308(10):L1046-57.
PMID: 25820525
Endothelial cell (EC) dysfunction plays a role in the pathobiology of occlusive vasculopathy in pulmonary arterial hypertension (PAH). Purinergic signaling pathways, which consist of extracellular nucleotide and nucleoside-mediated cell signaling...