Yann Grobs
Overview
Explore the profile of Yann Grobs including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
107
Followers
0
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Recent Articles
1.
Lemay S, Mougin M, Sauvaget M, El Kabbout R, Valasarajan C, Yamamoto K, et al.
Cell Rep Med
. 2025 Feb;
6(2):101964.
PMID: 39933527
Despite advances in treatment, the prognosis for patients with pulmonary arterial hypertension (PAH) remains dismal, highlighting the need for further therapeutic advances. By using RNA sequencing on pulmonary artery smooth...
2.
Lemay S, Montesinos M, Grobs Y, Yokokawa T, Shimauchi T, Mougin M, et al.
Circulation
. 2025 Jan;
PMID: 39829438
Background: Pulmonary arterial hypertension (PAH) is characterized by obliterative vascular remodeling of the small pulmonary arteries (PAs) and progressive increase in pulmonary vascular resistance leading to right ventricular failure. Although...
3.
Grobs Y, Romanet C, Lemay S, Bourgeois A, Voisine P, Theberge C, et al.
Sci Transl Med
. 2024 Dec;
16(777):eado7824.
PMID: 39661707
ATP citrate lyase (ACLY), a crucial enzyme in de novo lipid synthesis and histone acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation and survival. We...
4.
Grobs Y, Potus F
Am J Respir Cell Mol Biol
. 2024 Sep;
72(3):227-228.
PMID: 39288400
No abstract available.
5.
Lemay S, Montesinos M, Grobs Y, Yokokawa T, Shimauchi T, Romanet C, et al.
bioRxiv
. 2024 Jun;
PMID: 38854025
One Sentence Summary: The α5β1 integrin plays a crucial role in pulmonary vascular remodeling.
6.
Lemay S, Grobs Y, Romanet C, Martineau S, Salem M, Shimauchi T, et al.
Am J Respir Crit Care Med
. 2024 Jan;
209(11):1376-1391.
PMID: 38261723
The ubiquitous polyamine spermidine is essential for cell survival and proliferation. One important function of spermidine is to serve as a substrate for hypusination, a posttranslational modification process that occurs...
7.
Nayakanti S, Friedrich A, Sarode P, Jafari L, Maroli G, Boehm M, et al.
Circ Res
. 2023 Apr;
132(11):1468-1485.
PMID: 37042252
Background: The ability of the right ventricle (RV) to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. At present, there are no specific treatments...
8.
Lemay S, Grobs Y, Boucherat O
J Am Heart Assoc
. 2023 Mar;
12(6):e8285.
PMID: 36892086
No abstract available.
9.
Awada C, Bourgeois A, Lemay S, Grobs Y, Yokokawa T, Breuils-Bonnet S, et al.
Am J Respir Cell Mol Biol
. 2023 Feb;
68(5):537-550.
PMID: 36724371
Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling of small pulmonary arteries (PAs) causing sustained elevation of PA pressure, right ventricular failure, and death. Similar to cancer cells,...
10.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, et al.
JACC Basic Transl Sci
. 2022 May;
7(4):384-403.
PMID: 35540097
The authors show that increased poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with...