Olivier Boucherat
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Explore the profile of Olivier Boucherat including associated specialties, affiliations and a list of published articles.
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92
Citations
1842
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Recent Articles
1.
Lemay S, Mougin M, Sauvaget M, El Kabbout R, Valasarajan C, Yamamoto K, et al.
Cell Rep Med
. 2025 Feb;
6(2):101964.
PMID: 39933527
Despite advances in treatment, the prognosis for patients with pulmonary arterial hypertension (PAH) remains dismal, highlighting the need for further therapeutic advances. By using RNA sequencing on pulmonary artery smooth...
2.
Lemay S, Montesinos M, Grobs Y, Yokokawa T, Shimauchi T, Mougin M, et al.
Circulation
. 2025 Jan;
PMID: 39829438
Background: Pulmonary arterial hypertension (PAH) is characterized by obliterative vascular remodeling of the small pulmonary arteries (PAs) and progressive increase in pulmonary vascular resistance leading to right ventricular failure. Although...
3.
Grobs Y, Romanet C, Lemay S, Bourgeois A, Voisine P, Theberge C, et al.
Sci Transl Med
. 2024 Dec;
16(777):eado7824.
PMID: 39661707
ATP citrate lyase (ACLY), a crucial enzyme in de novo lipid synthesis and histone acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation and survival. We...
4.
Pi H, Xia L, Boucherat O, Suresh K, Hemnes A, Bonnet S, et al.
Circ Heart Fail
. 2024 Oct;
17(11):e012067.
PMID: 39435559
Background: Pulmonary arterial hypertension (PAH) is a disease of progressive right ventricular (RV) failure with high morbidity and mortality. Our goal is to investigate proteomic features and pathways associated with...
5.
Khassafi F, Chelladurai P, Valasarajan C, Nayakanti S, Martineau S, Sommer N, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(10):917-936.
PMID: 39196250
Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from...
6.
Boucherat O, Yokokawa T, Krishna V, Kalyana-Sundaram S, Martineau S, Breuils-Bonnet S, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(8):748-760.
PMID: 39196085
Although right ventricular (RV) function is the primary determinant of morbidity and mortality in pulmonary arterial hypertension (PAH), the molecular mechanisms of RV remodeling and the circulating factors reflecting its...
7.
Lemay S, Provencher S, Bonnet S, Potus F, Boucherat O
Ann Transl Med
. 2024 Jun;
12(3):55.
PMID: 38911559
No abstract available.
8.
Yokokawa T, Boucherat O, Martineau S, Lemay S, Breuils-Bonnet S, Krishna V, et al.
J Am Heart Assoc
. 2024 Jun;
13(12):e032888.
PMID: 38874078
Background: Pulmonary arterial hypertension (PAH) ultimately leads to right ventricular failure and premature death. The identification of circulating biomarkers with prognostic utility is considered a priority. As chronic inflammation is...
9.
Lemay S, Montesinos M, Grobs Y, Yokokawa T, Shimauchi T, Romanet C, et al.
bioRxiv
. 2024 Jun;
PMID: 38854025
One Sentence Summary: The α5β1 integrin plays a crucial role in pulmonary vascular remodeling.
10.
Tang H, Gupta A, Morrisroe S, Bao C, Schwantes-An T, Gupta G, et al.
Circulation
. 2024 May;
150(4):302-316.
PMID: 38695173
Background: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin...