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Roxane Paulin

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Articles 59
Citations 2866
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Recent Articles
1.
Bradley J, OShea P, Wrench C, Mattsson J, Paulin R, Overed-Sayer C, et al.
SLAS Discov . 2025 Mar; 32:100223. PMID: 40024445
Senescent cells contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease with significant unmet need and therefore, there is an interest in discovering new drug targets that regulate...
2.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, et al.
JACC Basic Transl Sci . 2022 May; 7(4):384-403. PMID: 35540097
The authors show that increased poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with...
3.
Jutras-Beaudoin N, Toro V, Lajoie A, Breuils-Bonnet S, Paulin R, Potus F
CJC Open . 2022 May; 4(4):357-363. PMID: 35495856
Background: The blood neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a powerful predictor of adverse outcomes in some cardiovascular and lung diseases. Pulmonary arterial hypertension (PAH) is a lethal vasculopathy...
4.
Wu W, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, et al.
Thorax . 2021 Jul; 77(3):247-258. PMID: 34226205
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are even worse when IPF results in...
5.
Malenfant S, Lebret M, Breton-Gagnon E, Potus F, Paulin R, Bonnet S, et al.
Eur Respir Rev . 2021 Apr; 30(160). PMID: 33853885
Exercise intolerance is a cardinal symptom of pulmonary arterial hypertension (PAH) and strongly impacts patients' quality of life (QoL). Although central cardiopulmonary impairments limit peak oxygen consumption ( ) in...
6.
Grobs Y, Awada C, Lemay S, Romanet C, Bourgeois A, Toro V, et al.
Int J Mol Sci . 2021 Apr; 22(6). PMID: 33805714
Trifluoperazine (TFP), an antipsychotic drug approved by the Food and Drug Administration, has been show to exhibit anti-cancer effects. Pulmonary arterial hypertension (PAH) is a devastating disease characterized by a...
7.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, et al.
Int J Mol Sci . 2021 Apr; 22(6). PMID: 33803922
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by a sustained elevation of pulmonary artery (PA) pressure, right ventricular failure, and premature death. Enhanced proliferation and resistance to apoptosis...
8.
Awada C, Grobs Y, Wu W, Habbout K, Romanet C, Breuils-Bonnet S, et al.
Eur Respir J . 2021 Jan; 57(5). PMID: 33446610
No abstract available.
9.
Vitry G, Paulin R, Grobs Y, Lampron M, Shimauchi T, Lemay S, et al.
Am J Respir Crit Care Med . 2020 Oct; 203(5):614-627. PMID: 33021405
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by abnormally elevated pulmonary pressures and right ventricular failure. Excessive proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells...
10.
Omura J, Habbout K, Shimauchi T, Wu W, Breuils-Bonnet S, Tremblay E, et al.
Circulation . 2020 Jul; 142(15):1464-1484. PMID: 32698630
Background: Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the recognized clinical importance of preserving RV...