Surya B Chhetri
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Explore the profile of Surya B Chhetri including associated specialties, affiliations and a list of published articles.
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13
Citations
1067
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Recent Articles
1.
Omdahl A, Weinstock J, Keener R, Chhetri S, Arvanitis M, Battle A
bioRxiv
. 2024 Dec;
PMID: 39651140
Complex trait-associated genetic variation is highly pleiotropic. This extensive pleiotropy implies that multi-phenotype analyses are informative for characterizing genetic associations, as they facilitate the discovery of trait-shared and trait-specific variants...
2.
Qi G, Chhetri S, Ray D, Dutta D, Battle A, Bhattacharjee S, et al.
Nat Commun
. 2024 Aug;
15(1):6985.
PMID: 39143063
Genome-wide association studies (GWAS) have found widespread evidence of pleiotropy, but characterization of global patterns of pleiotropy remain highly incomplete due to insufficient power of current approaches. We develop fastASSET,...
3.
Taylor D, Chhetri S, Tassia M, Biddanda A, Yan S, Wojcik G, et al.
Nature
. 2024 Jul;
632(8023):122-130.
PMID: 39020179
Genetic variation that influences gene expression and splicing is a key source of phenotypic diversity. Although invaluable, studies investigating these links in humans have been strongly biased towards participants of...
4.
Keener R, Chhetri S, Connelly C, Taub M, Conomos M, Weinstock J, et al.
Nat Commun
. 2024 May;
15(1):4417.
PMID: 38789417
Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere...
5.
Taylor D, Chhetri S, Tassia M, Biddanda A, Battle A, McCoy R
bioRxiv
. 2023 Nov;
PMID: 37965206
Genetic variation influencing gene expression and splicing is a key source of phenotypic diversity. Though invaluable, studies investigating these links in humans have been strongly biased toward participants of European...
6.
Rozowsky J, Gao J, Borsari B, Yang Y, Galeev T, Gursoy G, et al.
Cell
. 2023 Mar;
186(7):1493-1511.e40.
PMID: 37001506
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource...
7.
Das A, Sherry E, Vaughan R, Henderson M, Zieba J, Uhl K, et al.
Front Cell Dev Biol
. 2022 Dec;
10:1033695.
PMID: 36467401
The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the...
8.
Moore J, Purcaro M, Pratt H, Epstein C, Shoresh N, Adrian J, et al.
Nature
. 2022 Apr;
605(7909):E3.
PMID: 35474001
No abstract available.
9.
He Y, Chhetri S, Arvanitis M, Srinivasan K, Aguet F, Ardlie K, et al.
Genome Biol
. 2020 Sep;
21(1):235.
PMID: 32912314
Genetic regulation of gene expression, revealed by expression quantitative trait loci (eQTLs), exhibits complex patterns of tissue-specific effects. Characterization of these patterns may allow us to better understand mechanisms of...
10.
Moore J, Purcaro M, Pratt H, Epstein C, Shoresh N, Adrian J, et al.
Nature
. 2020 Jul;
583(7818):699-710.
PMID: 32728249
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III...