Mark J Wall
Overview
Explore the profile of Mark J Wall including associated specialties, affiliations and a list of published articles.
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73
Citations
1030
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Recent Articles
1.
Islam T, Hill E, Abrahamson E, Servaes S, Smirnov D, Zeng X, et al.
Nat Med
. 2025 Feb;
31(2):574-588.
PMID: 39930142
Patients with Alzheimer's disease (AD) with little or no quantifiable insoluble brain tau neurofibrillary tangle (NFT) pathology demonstrate stronger clinical benefits of therapies than those with advanced NFTs. The formation...
2.
Bhandare A, Haley M, Torrico Anderson V, Domingos L, Lopes M, Correa S, et al.
Epilepsia
. 2024 May;
65(7):2152-2164.
PMID: 38804501
Objectives: Pathological forms of neural activity, such as epileptic seizures, modify the expression pattern of multiple proteins, leading to persistent changes in brain function. One such protein is activity-regulated cytoskeleton-associated...
3.
Privitera L, Hogg E, Gaestel M, Wall M, Correa S
Neuropharmacology
. 2023 Nov;
242:109760.
PMID: 37914554
No abstract available.
4.
Haley M, Bertrand J, Torrico Anderson V, Fuad M, Frenguelli B, Correa S, et al.
Eur J Neurosci
. 2023 Oct;
58(10):4166-4180.
PMID: 37821126
Expression of the immediate early gene Arc/Arg3.1 (Arc), a key mediator of synaptic plasticity, is enhanced by neural activity and then reduced by proteasome-dependent degradation. We have previously shown that...
5.
Brown J, Grayson B, Neill J, Harte M, Wall M, Ngomba R
Cells
. 2023 Mar;
12(6).
PMID: 36980260
The cognitive deficits of schizophrenia are linked to imbalanced excitatory and inhibitory signalling in the prefrontal cortex (PFC), disrupting gamma oscillations. We previously demonstrated that two mGlu5 receptor-positive allosteric modulators...
6.
Hill E, Moffat K, Wall M, Zetterberg H, Blennow K, Karikari T
Methods Mol Biol
. 2022 Oct;
2551:203-224.
PMID: 36310205
There is growing evidence that tau oligomers are a major pathological species in a number of tauopathies including Alzheimer's disease. However, it is still unclear what exact mechanisms underlie tau...
7.
Hill E, Moffat K, Wall M, Zetterberg H, Blennow K, Karikari T
Methods Mol Biol
. 2022 Oct;
2551:147-161.
PMID: 36310202
Aggregated tau protein plays a key role in the pathogenesis of neurodegenerative tauopathies including Alzheimer's disease. Soluble, low-molecular-weight tau oligomers are formed early in disease processes and are thought to...
8.
Privitera L, Hogg E, Lopes M, Domingos L, Gaestel M, Muller J, et al.
Aging Cell
. 2022 Sep;
21(10):e13717.
PMID: 36135933
A key aim of Alzheimer disease research is to develop efficient therapies to prevent and/or delay the irreversible progression of cognitive impairments. Early deficits in long-term potentiation (LTP) are associated...
9.
Wall M, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, et al.
Nat Commun
. 2022 Jul;
13(1):4150.
PMID: 35851064
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous...
10.
Roberts R, Wall M, Braren I, Dhillon K, Evans A, Dunne J, et al.
Front Aging Neurosci
. 2022 Jul;
14:861344.
PMID: 35847678
Sleep apnoea is a highly prevalent disease that often goes undetected and is associated with poor clinical prognosis, especially as it exacerbates many different disease states. However, most animal models...