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Nicholas Dale

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Recent Articles
1.
Liang J, Ma K, Walker E, Johnson C, Zhao X, Terlier T, et al.
Small . 2025 Mar; :e2412750. PMID: 40087847
Forming heavily-doped regions in 2D materials, like graphene, is a steppingstone to the design of emergent devices and heterostructures. Here, a selective-area approach is presented to tune the work-function and...
2.
Nijjar S, Brotherton D, Butler J, Dospinescu V, Gannon H, Linthwaite V, et al.
J Physiol . 2025 Feb; 603(5):1071-1089. PMID: 39907096
CO directly modifies the gating of connexin26 (Cx26) gap junction channels and hemichannels. This gating depends upon Lys125, and the proposed mechanism involves carbamylation of Lys125 to allow formation of...
3.
Theparambil S, Kopach O, Braga A, Nizari S, Hosford P, Sagi-Kiss V, et al.
Nature . 2024 Jul; 632(8023):139-146. PMID: 38961289
Brain computation performed by billions of nerve cells relies on a sufficient and uninterrupted nutrient and oxygen supply. Astrocytes, the ubiquitous glial neighbours of neurons, govern brain glucose uptake and...
4.
Brotherton D, Nijjar S, Savva C, Dale N, Cameron A
Elife . 2024 Jun; 13. PMID: 38829031
Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO. This is proposed to be mediated through carbamylation of...
5.
Bhandare A, Dale N, Huckstepp R
Bio Protoc . 2024 May; 14(8):e4973. PMID: 38737784
In vivo brain imaging, using a combination of genetically encoded Ca indicators and gradient refractive index (GRIN) lens, is a transformative technology that has become an increasingly potent research tool...
6.
Bhandare A, Dale N
Front Cell Neurosci . 2024 Jan; 17:1288600. PMID: 38193031
While central autonomic, cardiac, and/or respiratory dysfunction underlies sudden unexpected death in epilepsy (SUDEP), the specific neural mechanisms that lead to SUDEP remain to be determined. In this study, we...
7.
Butler J, Dale N
Front Cell Neurosci . 2024 Jan; 17:1330983. PMID: 38188670
Connexin32 (Cx32) is expressed in myelinating Schwann cells. It forms both reflexive gap junctions, to facilitate transfer of molecules from the outer to the inner myelin layers and hemichannels at...
8.
Dale N, Utama M, Lee D, Leconte N, Zhao S, Lee K, et al.
Nano Lett . 2023 Jul; 23(15):6799-6806. PMID: 37486984
Near the magic angle, strong correlations drive many intriguing phases in twisted bilayer graphene (tBG) including unconventional superconductivity and chern insulation. Whether correlations can tune symmetry breaking phases in tBG...
9.
Dale N, Butler J, Dospinescu V, Nijjar S
Neuropharmacology . 2023 Jan; 227:109435. PMID: 36690324
ATP is well established as a transmitter and modulator in the peripheral and central nervous system. While conventional exocytotic release of ATP at synapses occurs, this transmitter is unusual in...
10.
Bhandare A, van de Wiel J, Roberts R, Braren I, Huckstepp R, Dale N
Elife . 2022 Oct; 11. PMID: 36300918
Regulation of systemic PCO is a life-preserving homeostatic mechanism. In the medulla oblongata, the retrotrapezoid nucleus (RTN) and rostral medullary Raphe are proposed as CO chemosensory nuclei mediating adaptive respiratory...