Carl L Manthey
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Explore the profile of Carl L Manthey including associated specialties, affiliations and a list of published articles.
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23
Citations
377
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Recent Articles
1.
Lee K, Lupancu T, Chang L, Manthey C, Zeeman M, Fourie A, et al.
Arthritis Res Ther
. 2024 Aug;
26(1):148.
PMID: 39107827
Objectives: We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here,...
2.
Lee K, Lupancu T, Chang L, Manthey C, Zeeman M, Fourie A, et al.
Cytokine
. 2024 Apr;
179:156619.
PMID: 38669908
Interleukin (IL)-23 is implicated in the pathogenesis of several inflammatory diseases and is usually linked with helper T cell (Th17) biology. However, there is some data linking IL-23 with innate...
3.
Manthey C, Moore B, Chen Y, Loza M, Yao X, Liu H, et al.
PLoS One
. 2019 Nov;
14(11):e0223918.
PMID: 31710624
Background & Aims: Originally believed to be primarily a disorder of T-cell signaling, evidence shows that macrophage-lineage cells also contribute to the pathogenesis of Crohn's disease (CD). Colony stimulating factor-1...
4.
Genovese M, Hsia E, Belkowski S, Chien C, Masterson T, Thurmond R, et al.
J Rheumatol
. 2015 Aug;
42(10):1752-60.
PMID: 26233509
Objective: To assess the efficacy and safety of JNJ-40346527, a selective inhibitor of colony-stimulating factor-1 (CSF-1) receptor kinase that acts to inhibit macrophage survival, proliferation, and differentiation in patients with...
5.
Illig C, Manthey C, Meegalla S, Wall M, Chen J, Wilson K, et al.
Bioorg Med Chem Lett
. 2013 Oct;
23(23):6363-9.
PMID: 24138939
Structure-activity relationship (SAR) studies on a highly potent series of arylamide FMS inhibitors were carried out with the aim of improving FMS kinase selectivity, particularly over KIT. Potent compound 17r...
6.
Han Y, Ma F, Tesch G, Manthey C, Nikolic-Paterson D
Am J Physiol Renal Physiol
. 2013 Feb;
304(8):F1043-53.
PMID: 23408165
The ability of macrophages to cause acute inflammatory glomerular injury is well-established; however, the role of macrophages in the fibrotic phase of chronic kidney disease remains poorly understood. This study...
7.
Illig C, Manthey C, Wall M, Meegalla S, Chen J, Wilson K, et al.
J Med Chem
. 2011 Nov;
54(22):7860-83.
PMID: 22039836
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities....
8.
Moore B, Manthey C, Johnson D, Bauer A
Gastroenterology
. 2011 Jun;
141(4):1283-92, 1292.e1-4.
PMID: 21703213
Background & Aims: Matrix metalloproteinase (MMP)-9, a member of the gelatinase family of MMPs, mediates leukocyte migration during inflammation. Inflammation contributes to development of postoperative ileus (POI), which is caused...
9.
Han Y, Ma F, Tesch G, Manthey C, Nikolic-Paterson D
Lab Invest
. 2011 Apr;
91(7):978-91.
PMID: 21519331
Depletion and adoptive transfer studies have demonstrated that macrophages induce glomerular lesions in experimental anti-glomerular basement membrane (anti-GBM) glomerulonephritis. However, there is no current therapeutic strategy that can rapidly and...
10.
Wilson K, Illig C, Chen J, Wall M, Ballentine S, DesJarlais R, et al.
Bioorg Med Chem Lett
. 2010 Jun;
20(13):3925-9.
PMID: 20570147
During efforts to improve the bioavailability of FMS kinase inhibitors 1 and 2, a series of saturated and aromatic 4-heterocycles of reduced basicity were prepared and evaluated in an attempt...