Mark Albertella
Overview
Explore the profile of Mark Albertella including associated specialties, affiliations and a list of published articles.
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7
Citations
516
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Recent Articles
1.
Herencia-Ropero A, Llop-Guevara A, Staniszewska A, Domenech-Vivo J, Garcia-Galea E, Moles-Fernandez A, et al.
Genome Med
. 2024 Aug;
16(1):107.
PMID: 39187844
Background: Poly (ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitors (PARPi) are targeted therapies approved for homologous recombination repair (HRR)-deficient breast, ovarian, pancreatic, and prostate cancers. Since inhibition of PARP1 is...
2.
Kerzeli I, Nasi A, Fletcher E, Chourlia A, Kallin A, Finnberg N, et al.
Cell Immunol
. 2024 Feb;
397-398:104814.
PMID: 38422979
The aim of this study was to assess the potential use of a selective small molecule MALT1 inhibitor in solid tumor treatment as an immunotherapy targeting regulatory T-cells (Tregs). In...
3.
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, et al.
Nature
. 2021 Apr;
593(7860):597-601.
PMID: 33902106
N-methyladenosine (mA) is an abundant internal RNA modification that is catalysed predominantly by the METTL3-METTL14 methyltransferase complex. The mA methyltransferase METTL3 has been linked to the initiation and maintenance of...
4.
Bankar A, Siriwardena T, Rizoska B, Rydergard C, Kylefjord H, Rraklli V, et al.
Haematologica
. 2019 Dec;
106(2):574-579.
PMID: 31857370
No abstract available.
5.
Yehudai D, Liyanage S, Hurren R, Rizoska B, Albertella M, Gronda M, et al.
Haematologica
. 2018 Dec;
104(5):963-972.
PMID: 30573504
Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ....
6.
Hornberger K, Chen X, Crew A, Kleinberg A, Ma L, Mulvihill M, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4511-6.
PMID: 23856049
The kinase selectivity and pharmacokinetic optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. The intersection of insights from molecular modeling, computational prediction of metabolic sites, and in...
7.
Hornberger K, Berger D, Crew A, Dong H, Kleinberg A, Li A, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4517-22.
PMID: 23850198
The discovery and potency optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. Micromolar hits taken from high-throughput screening were optimized for biochemical and cellular mechanistic potency to...