Mariya Morar
Overview
Explore the profile of Mariya Morar including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1964
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0
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Recent Articles
1.
Chai I, Kornyeyev D, Hsieh E, Magombedze G, Stapleton L, Hung M, et al.
Sci Rep
. 2022 Dec;
12(1):21286.
PMID: 36494467
The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody blockers of this interaction are an active area of...
2.
Niu B, Appleby T, Wang R, Morar M, Voight J, Villasenor A, et al.
Biochemistry
. 2019 Dec;
59(4):541-551.
PMID: 31841311
Blocking interactions between PD-1 and PD-L1 opens a new era of cancer treatment involving immunity modulation. Although most immunotherapies use monoclonal antibodies, small-molecule inhibitors offer advantages. To facilitate development of...
3.
Urbanus M, Quaile A, Stogios P, Morar M, Rao C, Di Leo R, et al.
Mol Syst Biol
. 2016 Dec;
12(12):893.
PMID: 27986836
Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined....
4.
McGregor N, Morar M, Fenger T, Stogios P, Lenfant N, Yin V, et al.
J Biol Chem
. 2015 Oct;
291(3):1175-97.
PMID: 26507654
The recent classification of glycoside hydrolase family 5 (GH5) members into subfamilies enhances the prediction of substrate specificity by phylogenetic analysis. However, the small number of well characterized members is...
5.
Morar M, Evdokimova E, Chang C, Ensminger A, Savchenko A
Proteins
. 2015 Oct;
83(12):2319-25.
PMID: 26426142
Legionella pneumophila, the intracellular pathogen that can cause severe pneumonia known as Legionnaire's disease, translocates close to 300 effectors inside the host cell using Dot/Icm type IVB secretion system. The...
6.
Stogios P, Evdokimova E, Morar M, Koteva K, Wright G, Courvalin P, et al.
J Mol Biol
. 2015 Apr;
427(12):2229-43.
PMID: 25900373
One of the main mechanisms of resistance to lincosamide and aminoglycoside antibiotics is their inactivation by O-nucleotidylyltransferases (NTases). Significant sequence variation of lincomycin nucleotidylyltransferase (Lnu) and aminoglycoside nucleotidylyltransferase (ANT) enzymes...
7.
McArthur A, Waglechner N, Nizam F, Yan A, Azad M, Baylay A, et al.
Antimicrob Agents Chemother
. 2013 May;
57(7):3348-57.
PMID: 23650175
The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements have yet to fully exploit the power of the genome revolution. Despite the fact that the...
8.
Morar M, Pengelly K, Koteva K, Wright G
Biochemistry
. 2012 Feb;
51(8):1740-51.
PMID: 22303981
Macrolide antibiotics such as azithromycin and erythromycin are mainstays of modern antibacterial chemotherapy, and like all antibiotics, they are vulnerable to resistance. One mechanism of macrolide resistance is via drug...
9.
DCosta V, King C, Kalan L, Morar M, Sung W, Schwarz C, et al.
Nature
. 2011 Sep;
477(7365):457-61.
PMID: 21881561
The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all...
10.
Morar M, Wright G
Annu Rev Genet
. 2010 Sep;
44:25-51.
PMID: 20822442
The need for new antibiotic therapies is acute and growing in large part because of the emergence of drug-resistant pathogens. A vast number of resistance determinants are, however, found in...