Aaron A Hoskins
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Explore the profile of Aaron A Hoskins including associated specialties, affiliations and a list of published articles.
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59
Citations
1007
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Recent Articles
1.
Liu Y, Nomura Y, Butcher S, Hoskins A
bioRxiv
. 2025 Mar;
PMID: 40060616
In eukaryotes, the process of intron removal from nuclear pre-mRNA is performed by the spliceosome, a dynamic molecular machine composed of small nuclear ribonucleoproteins (snRNPs; U1, U2, U4, U5, and...
2.
Fu X, Hoskins A
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39995036
Spliceosome assembly and catalytic activation involve dozens of protein and snRNA binding and unbinding events. The B-complex specific proteins (Prp38, Snu23, and Spp381) have critical roles in stabilizing the spliceosome...
3.
Beard J, Love S, Schmitz J, Hoskins A, Koide K
ACS Med Chem Lett
. 2024 Dec;
15(12):2225-2230.
PMID: 39691513
Meayamycins are synthetic analogs of the natural product FR901464 and exhibit potent anticancer activity against human cancers. They bind SF3B1 and PHF5A, components of the human spliceosome, and they alter...
4.
Senn K, Lipinski K, Zeps N, Griffin A, Wilkinson M, Hoskins A
Elife
. 2024 Dec;
13.
PMID: 39688371
Pre-mRNA splicing is catalyzed in two steps: 5' splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (first and...
5.
White D, Dunyak B, Vaillancourt F, Hoskins A
Nat Commun
. 2024 Oct;
15(1):8776.
PMID: 39389991
Splice site recognition is essential for defining the transcriptome. Drugs like risdiplam and branaplam change how human U1 snRNP recognizes particular 5' splice sites (5'SS) and promote U1 snRNP binding...
6.
Fu X, Hoskins A
bioRxiv
. 2024 Aug;
PMID: 39149324
Spliceosome assembly and catalytic site formation (called activation) involve dozens of protein and snRNA binding and unbinding events. The B-complex specific proteins Prp38, Snu23, and Spp381 have critical roles in...
7.
Senn K, Hoskins A
Wiley Interdiscip Rev RNA
. 2024 Jul;
15(4):e1866.
PMID: 38972853
Pre-mRNA splicing, the removal of introns and ligation of flanking exons, is a crucial step in eukaryotic gene expression. The spliceosome, a macromolecular complex made up of five small nuclear...
8.
Senn K, Lipinski K, Zeps N, Griffin A, Wilkinson M, Hoskins A
bioRxiv
. 2024 May;
PMID: 38746449
Pre-mRNA splicing is catalyzed in two steps: 5' splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (1 and...
9.
Carrocci T, DeMario S, He K, Zeps N, Harkner C, Chanfreau G, et al.
RNA
. 2024 May;
30(8):1058-1069.
PMID: 38719745
Identification of splice sites is a critical step in pre-messenger RNA (pre-mRNA) splicing because the definition of the exon/intron boundaries controls what nucleotides are incorporated into mature mRNAs. The intron...
10.
White D, Dunyak B, Vaillancourt F, Hoskins A
bioRxiv
. 2024 Apr;
PMID: 38659798
Splice site recognition is essential for defining the transcriptome. Drugs like risdiplam and branaplam change how U1 snRNP recognizes particular 5' splice sites (5'SS) and promote U1 snRNP binding and...