Alexei Savchenko
Overview
Explore the profile of Alexei Savchenko including associated specialties, affiliations and a list of published articles.
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Articles
193
Citations
4374
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Recent Articles
1.
Puumala E, Nandakumar M, Yiu B, Stogios P, Strickland B, Zarnowski R, et al.
Nat Commun
. 2025 Mar;
16(1):2156.
PMID: 40038303
Candida albicans is the most common cause of life-threatening fungal infection in the developed world but remains a therapeutic challenge. Protein kinases have been rewarding drug targets across diverse indications...
2.
Rosas-Lemus M, Minasov G, Brunzelle J, Taha T, Lemak S, Yin S, et al.
Protein Sci
. 2025 Feb;
34(3):e70050.
PMID: 39969084
Coronavirus non-structural protein 3 (nsp3) forms hexameric crowns of pores in the double membrane vesicle that houses the replication-transcription complex. Nsp3 in SARS-like viruses has three unique domains absent in...
3.
Agbavor C, Torres M, Inniss N, Latimer S, Minasov G, Shuvalova L, et al.
mSphere
. 2025 Jan;
10(2):e0107824.
PMID: 39878509
Importance: Streptococcal species are a leading cause of lower respiratory infections that annually affect millions of people worldwide. During infection, streptococcal species secrete a medley of virulence factors that allow...
4.
Cowen L, Puumala E, Nandakumar M, Yiu B, Stogios P, Strickland B, et al.
Res Sq
. 2025 Jan;
PMID: 39866870
is the most common cause of life-threatening fungal infection in the developed world but remains a therapeutic challenge. Protein kinases have been rewarding drug targets across diverse indications but remain...
5.
Patel D, Karimullina E, Guo Y, Semper C, Patel D, Emde T, et al.
Protein Sci
. 2025 Jan;
34(2):e70037.
PMID: 39865303
Polymyxins are last-resort antimicrobial peptides administered clinically against multi-drug resistant bacteria, specifically in the case of Gram-negative species. However, an increasing number of these pathogens employ a defense strategy that...
6.
Patel D, Stogios P, Jaroszewski L, Urbanus M, Sedova M, Semper C, et al.
Mol Syst Biol
. 2024 Nov;
21(1):59-89.
PMID: 39562741
Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds of effector proteins inside eukaryotic cells to ensure intracellular replication. Our understanding of the molecular functions of the...
7.
Patel D, Watanabe N, Savchenko A, Semper C
Proteins
. 2024 Sep;
93(3):569-574.
PMID: 39324284
Domains of unknown function (DUFs) continue to comprise a significant portion of bacterial proteomes, with more than 20% of bacterial proteins remaining annotated as DUFs. The characterization of their molecular...
8.
Rosas-Lemus M, Minasov G, Brunzelle J, Taha T, Lemak S, Yin S, et al.
bioRxiv
. 2024 Aug;
PMID: 39185168
Coronavirus non-structural protein 3 (nsp3) forms hexameric crowns of pores in the double membrane vacuole that houses the replication-transcription complex. Nsp3 in SARS-like viruses has three unique domains absent in...
9.
Khusnutdinova A, Tran H, Devlekar S, Distaso M, Kublanov I, Skarina T, et al.
FEMS Microbiol Ecol
. 2024 Aug;
100(9).
PMID: 39127612
Family GH1 glycosyl hydrolases are ubiquitous in prokaryotes and eukaryotes and are utilized in numerous industrial applications, including bioconversion of lignocelluloses. In this study, hyperacidophilic archaeon Cuniculiplasma divulgatum (S5T=JCM 30642T)...
10.
MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie N, Todd R, et al.
Nat Commun
. 2024 Aug;
15(1):6440.
PMID: 39090082
No abstract available.