Marilyn Leonard
Overview
Explore the profile of Marilyn Leonard including associated specialties, affiliations and a list of published articles.
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19
Citations
1186
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Recent Articles
1.
Monda J, Ge X, Hunkeler M, Donovan K, Ma M, Jin C, et al.
Cell Rep
. 2023 May;
42(5):112496.
PMID: 37167062
HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how...
2.
Garshott D, An H, Sundaramoorthy E, Leonard M, Vicary A, Harper J, et al.
Cell Rep
. 2021 Sep;
36(9):109642.
PMID: 34469731
Post-translational modification of ribosomal proteins enables rapid and dynamic regulation of protein biogenesis. Site-specific ubiquitylation of 40S ribosomal proteins uS10 and eS10 plays a key role during ribosome-associated quality control...
3.
Sundaramoorthy E, Ryan A, Fulzele A, Leonard M, Daugherty M, Bennett E
J Cell Sci
. 2021 Apr;
134(8).
PMID: 33912921
Viral infection both activates stress signaling pathways and redistributes ribosomes away from host mRNAs to translate viral mRNAs. The intricacies of this ribosome shuffle from host to viral mRNAs are...
4.
Garshott D, Sundaramoorthy E, Leonard M, Bennett E
Elife
. 2020 Feb;
9.
PMID: 32011234
Activation of the integrated stress response (ISR) or the ribosome-associated quality control (RQC) pathway stimulates regulatory ribosomal ubiquitylation (RRub) on distinct 40S ribosomal proteins, yet the cellular role and fate...
5.
Markmiller S, Fulzele A, Higgins R, Leonard M, Yeo G, Bennett E
Cell Rep
. 2019 May;
27(5):1356-1363.e3.
PMID: 31042464
Stress granule (SG) formation is frequently accompanied by ubiquitin proteasome system (UPS) impairment and ubiquitylated protein accumulation. SGs, ubiquitin, and UPS components co-localize, but the relationship between the ubiquitin pathway...
6.
Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett E
Mol Biol Cell
. 2018 Mar;
29(10):1258-1269.
PMID: 29540532
Previous genetic and biochemical studies from Saccharomyces cerevisiae have identified a critical ribosome-associated quality control complex (RQC) that facilitates resolution of stalled ribosomal complexes. While components of the mammalian RQC...
7.
Lumpkin R, Gu H, Zhu Y, Leonard M, Ahmad A, Clauser K, et al.
Nat Commun
. 2017 Oct;
8(1):1171.
PMID: 29079793
Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail...
8.
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett E
Mol Cell
. 2017 Jan;
65(4):751-760.e4.
PMID: 28132843
Ribosomes that experience terminal stalls during translation are resolved by ribosome-associated quality control (QC) pathways that oversee mRNA and nascent chain destruction and recycle ribosomal subunits. The proximal factors that...
9.
Doamekpor S, Lee J, Hepowit N, Wu C, Charenton C, Leonard M, et al.
Proc Natl Acad Sci U S A
. 2016 Jul;
113(29):E4151-60.
PMID: 27385828
The Ltn1 E3 ligase (listerin in mammals) has emerged as a paradigm for understanding ribosome-associated ubiquitylation. Ltn1 binds to 60S ribosomal subunits to ubiquitylate nascent polypeptides that become stalled during...
10.
Drakakaki G, Robert S, Szatmari A, Brown M, Nagawa S, Van Damme D, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(43):17850-5.
PMID: 22006339
Endomembrane trafficking relies on the coordination of a highly complex, dynamic network of intracellular vesicles. Understanding the network will require a dissection of cargo and vesicle dynamics at the cellular...