Elayanambi Sundaramoorthy
Overview
Explore the profile of Elayanambi Sundaramoorthy including associated specialties, affiliations and a list of published articles.
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14
Citations
538
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Recent Articles
1.
Kong L, Gupta K, Wu A, Perera D, Ivanyi-Nagy R, Ahmed S, et al.
Cell
. 2024 Apr;
187(9):2269-2287.e16.
PMID: 38608703
Knudson's "two-hit" paradigm posits that carcinogenesis requires inactivation of both copies of an autosomal tumor suppressor gene. Here, we report that the glycolytic metabolite methylglyoxal (MGO) transiently bypasses Knudson's paradigm...
2.
Garshott D, An H, Sundaramoorthy E, Leonard M, Vicary A, Harper J, et al.
Cell Rep
. 2021 Sep;
36(9):109642.
PMID: 34469731
Post-translational modification of ribosomal proteins enables rapid and dynamic regulation of protein biogenesis. Site-specific ubiquitylation of 40S ribosomal proteins uS10 and eS10 plays a key role during ribosome-associated quality control...
3.
Sundaramoorthy E, Ryan A, Fulzele A, Leonard M, Daugherty M, Bennett E
J Cell Sci
. 2021 Apr;
134(8).
PMID: 33912921
Viral infection both activates stress signaling pathways and redistributes ribosomes away from host mRNAs to translate viral mRNAs. The intricacies of this ribosome shuffle from host to viral mRNAs are...
4.
Sinha N, Ordureau A, Best K, Saba J, Zinshteyn B, Sundaramoorthy E, et al.
Elife
. 2020 Aug;
9.
PMID: 32744497
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to...
5.
Garshott D, Sundaramoorthy E, Leonard M, Bennett E
Elife
. 2020 Feb;
9.
PMID: 32011234
Activation of the integrated stress response (ISR) or the ribosome-associated quality control (RQC) pathway stimulates regulatory ribosomal ubiquitylation (RRub) on distinct 40S ribosomal proteins, yet the cellular role and fate...
6.
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett E
Mol Cell
. 2017 Jan;
65(4):751-760.e4.
PMID: 28132843
Ribosomes that experience terminal stalls during translation are resolved by ribosome-associated quality control (QC) pathways that oversee mRNA and nascent chain destruction and recycle ribosomal subunits. The proximal factors that...
7.
Jeyasekharan A, Liu Y, Hattori H, Pisupati V, Jonsdottir A, Rajendra E, et al.
Nat Struct Mol Biol
. 2013 Sep;
20(10):1191-8.
PMID: 24013206
Germline missense mutations affecting a single BRCA2 allele predispose humans to cancer. Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated mutation, BRCA2(D2723H), and that controls the...
8.
Silla Y, Sundaramoorthy E, Talwar P, Sengupta S
Amino Acids
. 2013 Feb;
44(5):1307-16.
PMID: 23400378
An elevated level of homocysteine, a thiol-containing amino acid is associated with a wide spectrum of disease conditions. A majority (>80 %) of the circulating homocysteine exist in protein-bound form....
9.
Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan A, Ayoub N, et al.
Curr Biol
. 2012 Aug;
22(18):1659-66.
PMID: 22863316
Background: The breast and ovarian cancer suppressor BRCA1 is essential for cellular responses to DNA damage. It heterodimerizes with BARD1 to acquire an E3 ubiquitin (Ub) ligase activity that is...
10.
Kumar J, Garg G, Kumar A, Sundaramoorthy E, Sanapala K, Ghosh S, et al.
Circ Cardiovasc Genet
. 2009 Dec;
2(6):599-606.
PMID: 20031640
Background: An elevated level of homocysteine (hyperhomocysteinemia) has been implicated as an independent risk factor for cardiovascular diseases. Deficiency of dietary factors like vitamin B(12), folate, and genetic variations can...