Marilyn H Perrin
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Explore the profile of Marilyn H Perrin including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tan L, Vaughan J, Perrin M, Rivier J, Sawchenko P
J Comp Neurol
. 2017 Aug;
525(18):3840-3864.
PMID: 28842924
The corticotropin-releasing factor (CRF) family of peptides includes CRF and three urocortins, which signal through two distinct G-protein coupled receptors, CRF and CRF . Although the cellular distribution of CRF...
2.
Pilbrow A, Lewis K, Perrin M, Sweet W, Moravec C, Tang W, et al.
Endocrinology
. 2016 Oct;
157(12):4865-4874.
PMID: 27754786
Corticotropin-releasing factor (CRF) and the CRF-related peptides, urocortin (Ucn)-1, Ucn2, and Ucn3 signal through receptors CRFR1 and CRFR2 to restore homeostasis in response to stress. The Ucns exert potent cardioprotective...
3.
Erchegyi J, Wang L, Gulyas J, Samant M, Perrin M, Lewis K, et al.
J Med Chem
. 2016 Jan;
59(3):854-66.
PMID: 26789203
CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties of astressin B analogues {cyclo(30-33)[D-Phe(12),Nle(21,38),C(α)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h/r-CRF(9-41)}. Out of 37 novel peptides, 17...
4.
Perrin M, Tan L, Vaughan J, Lewis K, Donaldson C, Miller C, et al.
J Pharmacol Exp Ther
. 2015 Mar;
353(2):307-17.
PMID: 25736419
The corticotropin-releasing factor (CRF) peptide family comprises the mammalian peptides CRF and the urocortins as well as frog skin sauvagine and fish urophyseal urotensin. Advances in understanding the roles of...
5.
Jappelli R, Perrin M, Lewis K, Vaughan J, Tzitzilonis C, Rivier J, et al.
PLoS One
. 2014 Jan;
9(1):e84013.
PMID: 24465390
Corticotropin-Releasing Factor Receptors (CRFRs) are class B1 G-protein-coupled receptors, which bind peptides of the corticotropin releasing factor family and are key mediators in the stress response. In order to dissect...
6.
Vaughan J, Donaldson C, Fischer W, Perrin M, Rivier J, Sawchenko P, et al.
Endocrinology
. 2013 Mar;
154(4):1553-64.
PMID: 23493376
Mouse (m) and human (h) urocortin 2 (Ucn 2) were identified by molecular cloning strategies and the primary sequence of their mature forms postulated by analogy to closely related members...
7.
Coin I, Perrin M, Vale W, Wang L
Angew Chem Int Ed Engl
. 2011 Jul;
50(35):8077-81.
PMID: 21751313
Capturing the right ligand at the right spot: a well-balanced system for non-natural amino acid mutagenesis allows the ligand binding sites of a class II G-protein coupled receptor to be...
8.
Klammt C, Perrin M, Maslennikov I, Renault L, Krupa M, Kwiatkowski W, et al.
Protein Sci
. 2011 Apr;
20(6):1030-41.
PMID: 21465615
G-protein coupled receptors (GPCRs) constitute the largest family of intercellular signaling molecules and are estimated to be the target of more than 50% of all modern drugs. As with most...
9.
Grace C, Perrin M, Gulyas J, Rivier J, Vale W, Riek R
J Biol Chem
. 2010 Sep;
285(49):38580-9.
PMID: 20843795
The corticotropin-releasing factor (CRF) peptide hormone family members coordinate endocrine, behavioral, autonomic, and metabolic responses to stress and play important roles within the cardiovascular, gastrointestinal, and central nervous systems, among...
10.
Maji S, Perrin M, Sawaya M, Jessberger S, Vadodaria K, Rissman R, et al.
Science
. 2009 Jun;
325(5938):328-32.
PMID: 19541956
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological...