Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

Overview

Journal Science

Specialty Science

Date 2009 Jun 23

PMID 19541956

Citations 416

Authors

Samir K Maji

Marilyn H Perrin

Michael R Sawaya

Sebastian Jessberger

Krishna Vadodaria

Robert A Rissman

Praful S Singru

K Peter R Nilsson

Rozalyn Simon

David Schubert

David Eisenberg

Jean Rivier

Paul Sawchenko

Wylie Vale

Roland Riek

Affiliations

Soon will be listed here.

Abstract

Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.

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