Joan M Vaughan
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Explore the profile of Joan M Vaughan including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
453
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Recent Articles
1.
Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli
Pai V, Lau C, Garcia-Ruiz A, Donaldson C, Vaughan J, Miller B, et al.
BMC Genomics
. 2024 Nov;
25(1):1034.
PMID: 39497054
Background: Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs). Most...
2.
Zlitni S, Bowden S, Sberro H, Torres M, Vaughan J, Pinto A, et al.
bioRxiv
. 2024 Aug;
PMID: 39185165
is a resident of the human gut, though upon translocation to the blood or body tissues, it can be pathogenic. Here we discover and characterize two peptide-based quorum-sensing systems that...
3.
Kim D, Park S, Park S, Ye M, Chen J, Kang S, et al.
Cell
. 2024 Jul;
187(18):5102-5117.e16.
PMID: 39043179
Neurons produce and release neuropeptides to communicate with one another. Despite their importance in brain function, circuit-based mechanisms of peptidergic transmission are poorly understood, primarily due to the lack of...
4.
Rocha A, Pai V, Perkins G, Chang T, Ma J, de Souza E, et al.
J Mol Biol
. 2024 Apr;
436(10):168559.
PMID: 38580077
Upstream open reading frames (uORFs) are cis-acting elements that can dynamically regulate the translation of downstream ORFs by suppressing downstream translation under basal conditions and, in some cases, increasing downstream...
5.
Xie L, Bowman M, Louie G, Zhang C, Ardejani M, Huang X, et al.
Biochemistry
. 2023 Oct;
62(21):3050-3060.
PMID: 37813856
Over the past decade, advances in genomics have identified thousands of additional protein-coding small open reading frames (smORFs) missed by traditional gene finding approaches. These smORFs encode peptides and small...
6.
Martinez T, Lyons-Abbott S, L Bookout A, de Souza E, Donaldson C, Vaughan J, et al.
Cell Metab
. 2023 Jan;
35(1):166-183.e11.
PMID: 36599300
Microproteins (MPs) are a potentially rich source of uncharacterized metabolic regulators. Here, we use ribosome profiling (Ribo-seq) to curate 3,877 unannotated MP-encoding small ORFs (smORFs) in primary brown, white, and...
7.
Tan D, Konduri S, Ertunc M, Zhang P, Wang J, Chang T, et al.
Nat Chem Biol
. 2022 Oct;
19(2):187-197.
PMID: 36266352
Lipids contribute to the structure, development, and function of healthy brains. Dysregulated lipid metabolism is linked to aging and diseased brains. However, our understanding of lipid metabolism in aging brains...
8.
Ostojic J, Yoon Y, Sonntag T, Nguyen B, Vaughan J, Shokhirev M, et al.
Cell Rep
. 2021 May;
35(7):109136.
PMID: 34010639
The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1-3 (CRTC1-3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear....
9.
Ertunc M, Kok B, Parsons W, Wang J, Tan D, Donaldson C, et al.
J Biol Chem
. 2020 Mar;
295(18):5891-5905.
PMID: 32152231
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing...
10.
Chu Q, Martinez T, Novak S, Donaldson C, Tan D, Vaughan J, et al.
Nat Commun
. 2019 Oct;
10(1):4883.
PMID: 31653868
Cellular homeostasis relies on having dedicated and coordinated responses to a variety of stresses. The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a common stress that triggers...