Photo-cross-linkers Incorporated into G-protein-coupled Receptors in Mammalian Cells: a Ligand Comparison

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2011 Jul 14

PMID 21751313

Citations 33

Authors

Irene Coin

Marilyn H Perrin

Wylie W Vale

Lei Wang

Affiliations

Soon will be listed here.

Abstract

Capturing the right ligand at the right spot: a well-balanced system for non-natural amino acid mutagenesis allows the ligand binding sites of a class II G-protein coupled receptor to be mapped and distinct binding domains to be identified for different ligands in the native environment of mammalian cells.

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