Maria L Toribio
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Explore the profile of Maria L Toribio including associated specialties, affiliations and a list of published articles.
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43
Citations
1212
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Recent Articles
11.
Fuentes P, Toribio M, Gonzalez-Garcia S
Methods Mol Biol
. 2020 Nov;
2185:215-239.
PMID: 33165851
Intense chemotherapy regimens of patients diagnosed with T cell acute lymphoblastic leukemia (T-ALL) have proved successful for improving patient's overall survival, especially in children. But still T-ALL treatment remains challenging,...
12.
Bayon-Calderon F, Toribio M, Gonzalez-Garcia S
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33081391
T-cell acute lymphoblastic leukemia (T-ALL), a T-cell malignant disease that mainly affects children, is still a medical challenge, especially for refractory patients for whom therapeutic options are scarce. Recent advances...
13.
Silkenstedt E, Arenas F, Colom-Sanmarti B, Xargay-Torrent S, Higashi M, Giro A, et al.
J Exp Clin Cancer Res
. 2019 Nov;
38(1):446.
PMID: 31676012
Background: NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5-10% of cases and are associated with significantly shorter survival rates. The present study aimed to...
14.
Lopez-Guerra M, Xargay-Torrent S, Fuentes P, Roldan J, Gonzalez-Farre B, Rosich L, et al.
Oncogene
. 2019 Oct;
39(6):1185-1197.
PMID: 31616059
Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), particularly in NOTCH1-mutated patients. We provide first evidence that the Notch ligand DLL4 is a...
15.
Gonzalez-Garcia S, Mosquera M, Fuentes P, Palumbo T, Escudero A, Perez-Martinez A, et al.
Blood
. 2019 Sep;
134(24):2171-2182.
PMID: 31530562
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy resulting from the dysregulation of signaling pathways that control intrathymic T-cell development. Relapse rates are still significant, and prognosis is...
16.
Garcia-Leon M, Fuentes P, de la Pompa J, Toribio M
Development
. 2018 Jul;
145(16).
PMID: 30042180
T-cell development is a complex dynamic process that relies on ordered stromal signals delivered to thymus-seeding progenitors that migrate throughout different thymus microenvironments (TMEs). Particularly, Notch signaling provided by thymic...
17.
Garcia-Peydro M, Fuentes P, Mosquera M, Garcia-Leon M, Alcain J, Rodriguez A, et al.
J Clin Invest
. 2018 May;
128(7):2802-2818.
PMID: 29781813
NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL), but crucial NOTCH1 downstream signals and target genes contributing to T-ALL pathogenesis cannot be retrospectively analyzed in...
18.
Robles-Valero J, Lorenzo-Martin L, Menacho-Marquez M, Fernandez-Pisonero I, Abad A, Camos M, et al.
Cancer Cell
. 2017 Nov;
32(5):608-623.e9.
PMID: 29136506
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their...
19.
Martin-Gayo E, Gonzalez-Garcia S, Garcia-Leon M, Murcia-Ceballos A, Alcain J, Garcia-Peydro M, et al.
J Exp Med
. 2017 Sep;
214(11):3361-3379.
PMID: 28947612
A key unsolved question regarding the developmental origin of conventional and plasmacytoid dendritic cells (cDCs and pDCs, respectively) resident in the steady-state thymus is whether early thymic progenitors (ETPs) could...
20.
Sanchez-Diaz R, Blanco-Dominguez R, Lasarte S, Tsilingiri K, Martin-Gayo E, Linillos-Pradillo B, et al.
Mol Cell Biol
. 2017 Feb;
37(9).
PMID: 28167605
Thymus-derived regulatory T (tTreg) cells are key to preventing autoimmune diseases, but the mechanisms involved in their development remain unsolved. Here, we show that the C-type lectin receptor CD69 controls...