Margarita C Dinamarca
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Explore the profile of Margarita C Dinamarca including associated specialties, affiliations and a list of published articles.
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16
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583
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Recent Articles
11.
Dinamarca M, Arrazola M, Toledo E, Cerpa W, Hancke J, Inestrosa N
Chem Biol Interact
. 2008 Jul;
175(1-3):142-9.
PMID: 18599028
The major protein constituent of amyloid deposits in Alzheimer's disease (AD) is the amyloid-beta-peptide (Abeta). Amyloid deposits contain "chaperone molecules" which play critical roles in amyloid formation and toxicity. In...
12.
Cerpa W, Dinamarca M, Inestrosa N
Curr Alzheimer Res
. 2008 Jun;
5(3):233-43.
PMID: 18537540
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A characteristic of AD is the accumulation of plaques in the brain of AD...
13.
Dinamarca M, Colombres M, Cerpa W, Bonansco C, Inestrosa N
Neurodegener Dis
. 2008 Mar;
5(3-4):149-52.
PMID: 18322375
Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. Synaptic dysfunction is an early manifestation of AD. The cellular mechanism by which...
14.
Inestrosa N, Dinamarca M, Alvarez A
FEBS J
. 2008 Jan;
275(4):625-32.
PMID: 18205831
Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies have indicated that acetylcholinesterase induces amyloid fibril formation by interaction throughout the peripherical anionic site of the enzyme forming highly...
15.
Santos M, Quintanilla R, Toro A, Grandy R, Dinamarca M, Godoy J, et al.
J Biol Chem
. 2005 Oct;
280(49):41057-68.
PMID: 16204253
Alzheimer disease is a neurodegenerative process that leads to severe cognitive impairment as a consequence of selective death of neuronal populations. The molecular pathogenesis of Alzheimer disease involves the participation...
16.
Inestrosa N, Alvarez A, Dinamarca M, Perez-Acle T, Colombres M
Curr Alzheimer Res
. 2005 Jun;
2(3):301-6.
PMID: 15974895
The cholinergic system impairment observed in Alzheimer's disease (AD) patients leads to the cognitive, global and behavioral dysfunction commonly associated with dementia. The only treatment for AD has been the...
17.
Reyes A, Chacon M, Dinamarca M, Cerpa W, Morgan C, Inestrosa N
Am J Pathol
. 2004 May;
164(6):2163-74.
PMID: 15161650
Neuropathological changes generated by human amyloid-beta peptide (Abeta) fibrils and Abeta-acetylcholinesterase (Abeta-AChE) complexes were compared in rat hippocampus in vivo. Results showed that Abeta-AChE complexes trigger a more dramatic response...