Thorsten Fritzius
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Explore the profile of Thorsten Fritzius including associated specialties, affiliations and a list of published articles.
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22
Citations
630
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Recent Articles
1.
Perez-Garci E, Pysanenko K, Rizzi G, Studer F, Ulrich D, Fritzius T, et al.
Neurobiol Dis
. 2025 Feb;
206:106831.
PMID: 39914775
During GABAergic synaptic transmission, G protein-coupled GABA receptors (GBRs) activate K channels that prolong the duration of inhibitory postsynaptic potentials (IPSPs). We now show that KCTD16, an auxiliary GBR subunit,...
2.
Fruh S, Boudkkazi S, Koppensteiner P, Sereikaite V, Chen L, Fernandez-Fernandez D, et al.
Sci Adv
. 2024 Jul;
10(28):eadk5462.
PMID: 38985877
Adherens junction-associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid...
3.
Trovo L, Kouvaros S, Schwenk J, Fernandez-Fernandez D, Fritzius T, Rem P, et al.
EMBO Rep
. 2024 May;
25(6):2610-2634.
PMID: 38698221
GABA receptors (GBRs), the G protein-coupled receptors for GABA, regulate synaptic transmission throughout the brain. A main synaptic function of GBRs is the gating of Cav2.2-type Ca channels. However, the...
4.
Fritzius T, Turecek R, Fernandez-Fernandez D, Isogai S, Rem P, Kralikova M, et al.
Biochem Pharmacol
. 2024 Mar;
228:116176.
PMID: 38555036
GABA receptors (GBRs) are G protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. GBRs regulate fast synaptic transmission by gating Ca and K channels via the Gβγ...
5.
Rem P, Sereikaite V, Fernandez-Fernandez D, Reinartz S, Ulrich D, Fritzius T, et al.
Elife
. 2023 Jan;
12.
PMID: 36688536
Amyloid-β precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. APP and sAPP were reported to bind to the extracellular sushi...
6.
Bhandari P, Vandael D, Fernandez-Fernandez D, Fritzius T, Kleindienst D, Onal C, et al.
Elife
. 2021 Apr;
10.
PMID: 33913808
The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca channels (Cav2.3) and auxiliary GABA receptor (GBR) subunits, the...
7.
Werthmann R, Tzouros M, Lamerz J, Augustin A, Fritzius T, Trovo L, et al.
Neuropharmacology
. 2020 Dec;
190:108426.
PMID: 33279506
For a long time metabotropic glutamate receptors (mGluRs) were thought to regulate neuronal functions as obligatory homodimers. Recent reports, however, indicate the existence of heterodimers between group-II and -III mGluRs...
8.
Fritzius T, Stawarski M, Isogai S, Bettler B
Curr Top Behav Neurosci
. 2020 Aug;
52:19-37.
PMID: 32812202
GABA receptors (GBRs), the G protein-coupled receptors for the inhibitory neurotransmitter γ-aminobutyric acid (GABA), activate Go/i-type G proteins that regulate adenylyl cyclase, Ca channels, and K channels. GBR signaling to...
9.
Sereikaite V, Fritzius T, Kasaragod V, Bader N, Maric H, Schindelin H, et al.
J Med Chem
. 2019 Sep;
62(19):8819-8830.
PMID: 31509708
Targeting multiprotein receptor complexes, rather than receptors directly, is a promising concept in drug discovery. This is particularly relevant to the GABA receptor complex, which plays a prominent role in...
10.
Fritzius T, Bettler B
Basic Clin Pharmacol Toxicol
. 2019 Apr;
126 Suppl 6:25-34.
PMID: 31033219
GABA receptors (GBRs), the G protein-coupled receptors for the neurotransmitter γ-aminobutyric acid (GABA), regulate synaptic transmission at most synapses in the brain. Proteomic approaches revealed that native GBR complexes assemble...