Marcus Schewe
Overview
Explore the profile of Marcus Schewe including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
17
Citations
395
Followers
0
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Related Specialties
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Recent Articles
11.
Nematian-Ardestani E, Abd-Wahab F, Chatelain F, Sun H, Schewe M, Baukrowitz T, et al.
J Biol Chem
. 2019 Dec;
295(2):610-618.
PMID: 31806709
Two-pore domain K (K2P) channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/) K2P channel remain poorly characterized because heterologous expression of this ion channel...
12.
Rinne S, Kiper A, Vowinkel K, Ramirez D, Schewe M, Bedoya M, et al.
Elife
. 2019 Feb;
8.
PMID: 30803485
Two-pore-domain potassium (K) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of...
13.
Schewe M, Sun H, Mert U, Mackenzie A, Pike A, Schulz F, et al.
Science
. 2019 Feb;
363(6429):875-880.
PMID: 30792303
Potassium (K) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of...
14.
Silbernagel N, Walecki M, Schafer M, Kessler M, Zobeiri M, Rinne S, et al.
FASEB J
. 2018 Jun;
32(11):6159-6173.
PMID: 29879376
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels encode neuronal and cardiac pacemaker currents. The composition of pacemaker channel complexes in different tissues is poorly understood, and the presence of additional HCN modulating...
15.
Aryal P, Jarerattanachat V, Clausen M, Schewe M, McClenaghan C, Argent L, et al.
Structure
. 2017 Apr;
25(5):708-718.e2.
PMID: 28392258
The mechanosensitive two-pore domain (K2P) K channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here...
16.
Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper A, Rinne S, et al.
EMBO Mol Med
. 2017 Mar;
9(4):403-414.
PMID: 28242754
In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch-activated K potassium channel TREK-1 ( or K2.1)....
17.
McClenaghan C, Schewe M, Aryal P, Carpenter E, Baukrowitz T, Tucker S
J Gen Physiol
. 2016 Jun;
147(6):497-505.
PMID: 27241700
The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two...
18.
Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, et al.
Cell
. 2016 Feb;
164(5):937-49.
PMID: 26919430
Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background "leak" conductance. In some K2P channels, strong voltage-dependent activation has been observed,...