Karin E J Rodstrom
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Explore the profile of Karin E J Rodstrom including associated specialties, affiliations and a list of published articles.
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11
Citations
150
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Recent Articles
1.
Rodstrom K, Eymsh B, Proks P, Hayre M, Cordeiro S, Mendez-Otalvaro E, et al.
Nat Struct Mol Biol
. 2025 Feb;
PMID: 40011745
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K channel implicated in microglial activation and neuroinflammation, and a current target for the treatment of neurodegenerative disorders, for example...
2.
Hall P, Jouen-Tachoire T, Schewe M, Proks P, Baukrowitz T, Carpenter E, et al.
Structure
. 2024 Dec;
33(1):115-122.e4.
PMID: 39637865
TASK-1 and TASK-3 are pH-sensitive two-pore domain (K2P/KCNK) K channels. Their functional roles make them promising targets for treatment of multiple disorders including sleep apnea, pain, and atrial fibrillation. Mutations...
3.
Li H, Pike A, Lotsaris I, Chi G, Hansen J, Lee S, et al.
Nat Commun
. 2024 Jul;
15(1):5503.
PMID: 38951531
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and...
4.
Rodstrom K, Cloake A, Sormann J, Baronina A, Smith K, Pike A, et al.
Nat Commun
. 2024 May;
15(1):4173.
PMID: 38755204
Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification...
5.
Sormann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel E, et al.
Nat Genet
. 2022 Oct;
54(10):1534-1543.
PMID: 36195757
Sleep apnea is a common disorder that represents a global public health burden. KCNK3 encodes TASK-1, a K channel implicated in the control of breathing, but its link with sleep...
6.
Proks P, Schewe M, Conrad L, Rao S, Rathje K, Rodstrom K, et al.
J Gen Physiol
. 2021 May;
153(8).
PMID: 34032848
The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by...
7.
Rodstrom K, Kiper A, Zhang W, Rinne S, Pike A, Goldstein M, et al.
Nature
. 2020 Jun;
582(7812):443-447.
PMID: 32499642
TWIK-related acid-sensitive potassium (TASK) channels-members of the two pore domain potassium (K) channel family-are found in neurons, cardiomyocytes and vascular smooth muscle cells, where they are involved in the regulation...
8.
Rodstrom K, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K
Sci Rep
. 2016 May;
6:25796.
PMID: 27180909
Superantigens are toxins produced by Staphylococcus aureus, called staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T cell receptor (TCR) and major histocompatibility complex class II, triggering a...
9.
Rodstrom K, Lindkvist-Petersson K
Methods Mol Biol
. 2015 Dec;
1396:51-65.
PMID: 26676036
Structure determination of superantigens and the complexes they form with immune receptors have over the years provided insight in their modes of action. This technique requires growing large and highly...
10.
Rodstrom K, Regenthal P, Lindkvist-Petersson K
PLoS One
. 2015 Jul;
10(7):e0131988.
PMID: 26147596
T cells are crucial players in cell-mediated immunity. The specificity of their receptor, the T cell receptor (TCR), is central for the immune system to distinguish foreign from host antigens....