Marcus Schewe
Overview
Explore the profile of Marcus Schewe including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
395
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0
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Recent Articles
1.
Rodstrom K, Eymsh B, Proks P, Hayre M, Cordeiro S, Mendez-Otalvaro E, et al.
Nat Struct Mol Biol
. 2025 Feb;
PMID: 40011745
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K channel implicated in microglial activation and neuroinflammation, and a current target for the treatment of neurodegenerative disorders, for example...
2.
Hall P, Jouen-Tachoire T, Schewe M, Proks P, Baukrowitz T, Carpenter E, et al.
Structure
. 2024 Dec;
33(1):115-122.e4.
PMID: 39637865
TASK-1 and TASK-3 are pH-sensitive two-pore domain (K2P/KCNK) K channels. Their functional roles make them promising targets for treatment of multiple disorders including sleep apnea, pain, and atrial fibrillation. Mutations...
3.
Neelsen L, Riel E, Rinne S, Schmid F, Jurs B, Bedoya M, et al.
Nat Commun
. 2024 Aug;
15(1):7545.
PMID: 39215031
Two-pore domain K (K) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower...
4.
Turkaydin B, Schewe M, Riel E, Schulz F, Biedermann J, Baukrowitz T, et al.
Nat Commun
. 2024 May;
15(1):4628.
PMID: 38821927
The two-pore domain potassium (K) channels TREK-1 and TREK-2 link neuronal excitability to a variety of stimuli including mechanical force, lipids, temperature and phosphorylation. This regulation involves the C-terminus as...
5.
Rodstrom K, Cloake A, Sormann J, Baronina A, Smith K, Pike A, et al.
Nat Commun
. 2024 May;
15(1):4173.
PMID: 38755204
Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification...
6.
Schroeter C, Nelke C, Schewe M, Spohler L, Herrmann A, Muntefering T, et al.
Biol Chem
. 2023 Feb;
404(4):355-375.
PMID: 36774650
Modulation of two-pore domain potassium (K) channels has emerged as a novel field of therapeutic strategies as they may regulate immune cell activation and metabolism, inflammatory signals, or barrier integrity....
7.
Sormann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel E, et al.
Nat Genet
. 2022 Oct;
54(10):1534-1543.
PMID: 36195757
Sleep apnea is a common disorder that represents a global public health burden. KCNK3 encodes TASK-1, a K channel implicated in the control of breathing, but its link with sleep...
8.
Riel E, Jurs B, Cordeiro S, Musinszki M, Schewe M, Baukrowitz T
J Gen Physiol
. 2021 Dec;
154(2).
PMID: 34928298
Work over the past three decades has greatly advanced our understanding of the regulation of Kir K+ channels by polyanionic lipids of the phosphoinositide (e.g., PIP2) and fatty acid metabolism...
9.
Chang W, Matt A, Schewe M, Musinszki M, Grussel S, Brandenburg J, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34301868
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and statoconia in vertebrates but whose underlying cellular mechanisms remain largely unknown. Here, we...
10.
Proks P, Schewe M, Conrad L, Rao S, Rathje K, Rodstrom K, et al.
J Gen Physiol
. 2021 May;
153(8).
PMID: 34032848
The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by...