Marco Jost
Overview
Explore the profile of Marco Jost including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
2006
Followers
0
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Recent Articles
1.
Glick V, Webber C, Simmons L, Martin M, Ahmad M, Kim C, et al.
Cell Host Microbe
. 2024 Oct;
32(11):1897-1909.e7.
PMID: 39423813
The optimal vaginal microbiome is a Lactobacillus-dominant community. Apart from Lactobacillus iners, the presence of Lactobacillus species is associated with reduced vaginal inflammation and reduced levels of pro-inflammatory cytokines. Loss...
2.
Russell B, Verma M, Maier N, Jost M
Curr Opin Microbiol
. 2024 Oct;
82:102554.
PMID: 39368241
Interrogation of host-microbe interactions has long been a source of both basic discoveries and benefits to human health. Here, we review the role that functional genomics approaches have played in...
3.
Vaccaro F, Faber D, Andree G, Born D, Kang G, Fonseca D, et al.
J Biol Chem
. 2023 Jul;
299(9):105109.
PMID: 37517695
G-protein metallochaperones are essential for the proper maturation of numerous metalloenzymes. The G-protein chaperone MMAA in humans (MeaB in bacteria) uses GTP hydrolysis to facilitate the delivery of adenosylcobalamin (AdoCbl)...
4.
Clark I, Fontanez K, Meltzer R, Xue Y, Hayford C, May-Zhang A, et al.
Nat Biotechnol
. 2023 Mar;
41(11):1557-1566.
PMID: 36879006
Current single-cell RNA-sequencing approaches have limitations that stem from the microfluidic devices or fluid handling steps required for sample processing. We develop a method that does not require specialized microfluidic...
5.
Replogle J, Bonnar J, Pogson A, Liem C, Maier N, Ding Y, et al.
Elife
. 2022 Dec;
11.
PMID: 36576240
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell...
6.
Zhang Y, Jost M, Pak R, Lu D, Li J, Lomenick B, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2205608119.
PMID: 36037385
Cop9 signalosome (CSN) regulates the function of cullin-RING E3 ubiquitin ligases (CRLs) by deconjugating the ubiquitin-like protein NEDD8 from the cullin subunit. To understand the physiological impact of CSN function...
7.
Tolani B, Celli A, Yao Y, Tan Y, Fetter R, Liem C, et al.
Nat Biotechnol
. 2022 Jul;
40(12):1834-1844.
PMID: 35879364
Mutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, we screened for...
8.
Replogle J, Saunders R, Pogson A, Hussmann J, Lenail A, Guna A, et al.
Cell
. 2022 Jun;
185(14):2559-2575.e28.
PMID: 35688146
A central goal of genetics is to define the relationships between genotypes and phenotypes. High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single-cell RNA-sequencing readouts) enable massively parallel functional...
9.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, et al.
Elife
. 2021 May;
10.
PMID: 34034859
Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under...
10.
Jost M, Jacobson A, Hussmann J, Cirolia G, Fischbach M, Weissman J
Elife
. 2021 Apr;
10.
PMID: 33904395
Dendritic cells (DCs) regulate processes ranging from antitumor and antiviral immunity to host-microbe communication at mucosal surfaces. It remains difficult, however, to genetically manipulate human DCs, limiting our ability to...