Luke A Gilbert
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Explore the profile of Luke A Gilbert including associated specialties, affiliations and a list of published articles.
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12607
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Recent Articles
1.
Lin K, Zou C, Hubbard A, Sengelmann S, Goudy L, Wang I, et al.
Neuro Oncol
. 2025 Feb;
PMID: 39998382
Background: Glioblastoma (GBM) carries a poor prognosis, and new therapeutic strategies are necessary to improve outcomes for patients with this disease. Alkylating chemotherapies including temozolomide (TMZ) and lomustine (CCNU) are...
2.
Adli M, Przybyla L, Burdett T, Burridge P, Cacheiro P, Chang H, et al.
Nature
. 2025 Feb;
638(8050):351-359.
PMID: 39939790
Recent advances in functional genomics and human cellular models have substantially enhanced our understanding of the structure and regulation of the human genome. However, our grasp of the molecular functions...
3.
Fu B, Xu A, Li H, Johnson D, Grandis J, Gilbert L
bioRxiv
. 2025 Feb;
PMID: 39896609
Mutations in the FA pathway lead to a rare genetic disease that increases risk of bone marrow failure, acute myeloid leukemia, and solid tumors. FA patients have a 500 to...
4.
Chesner L, Polesso F, Graff J, Hawley J, Smith A, Lundberg A, et al.
Cancer Discov
. 2024 Dec;
15(3):481-494.
PMID: 39652470
Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This...
5.
Berquez M, Li A, Luy M, Venida A, OLoughlin T, Rademaker G, et al.
bioRxiv
. 2024 Nov;
PMID: 39554122
Pancreatic ductal adenocarcinoma (PDA) evades immune detection partly via autophagic capture and lysosomal degradation of major histocompatibility complex class I (MHC-I). Why MHC-I is susceptible to capture via autophagy remains...
6.
Wilson C, Pommier G, Richman D, Sambold N, Hussmann J, Weissman J, et al.
bioRxiv
. 2024 Nov;
PMID: 39554033
Understanding how human gene expression is coordinately regulated by functional units of proteins across the genome remains a major biological goal. Here, we present COMET, a high-throughput screening platform for...
7.
Ge A, Arab A, Dai R, Navickas A, Fish L, Garcia K, et al.
Sci Rep
. 2024 Oct;
14(1):25940.
PMID: 39472491
No abstract available.
8.
Liu S, Zou C, Pak J, Morse A, Pang D, Casey-Clyde T, et al.
Genome Biol
. 2024 Oct;
25(1):256.
PMID: 39375777
Background: Genetic perturbation screens with single-cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such...
9.
Umhoefer J, Arce M, Whalen S, Dajani R, Goudy L, Kasinathan S, et al.
bioRxiv
. 2024 Sep;
PMID: 39282425
FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T...
10.
Woo B, Moussavi-Baygi R, Karner H, Karimzadeh M, Yousefi H, Lee S, et al.
Cell Rep
. 2024 Sep;
43(9):114764.
PMID: 39276353
Large-scale sequencing efforts have been undertaken to understand the mutational landscape of the coding genome. However, the vast majority of variants occur within non-coding genomic regions. We designed an integrative...