Joseph M Replogle
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Explore the profile of Joseph M Replogle including associated specialties, affiliations and a list of published articles.
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33
Citations
2299
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Recent Articles
1.
Nadig A, Replogle J, Pogson A, McCarroll S, Weissman J, Robinson E, et al.
bioRxiv
. 2024 Jul;
PMID: 39005298
Single cell CRISPR screens such as Perturb-seq enable transcriptomic profiling of genetic perturbations at scale. However, the data produced by these screens are often noisy due to cost and technical...
2.
Do B, Hsu P, Vermeulen S, Wang Z, Hirz T, Abbott K, et al.
Dev Cell
. 2024 Jun;
59(16):2203-2221.e15.
PMID: 38823395
Control of cellular identity requires coordination of developmental programs with environmental factors such as nutrient availability, suggesting that perturbing metabolism can alter cell state. Here, we find that nucleotide depletion...
3.
Guna A, Page K, Replogle J, Esantsi T, Wang M, Weissman J, et al.
BMC Genomics
. 2023 Oct;
24(1):651.
PMID: 37904134
Mapping genetic interactions is essential for determining gene function and defining novel biological pathways. We report a simple to use CRISPR interference (CRISPRi) based platform, compatible with Fluorescence Activated Cell...
4.
Koblan L, Arbab M, Shen M, Hussmann J, Anzalone A, Doman J, et al.
Nat Biotechnol
. 2023 Oct;
41(11):1655.
PMID: 37853259
No abstract available.
5.
Sunshine S, Puschnik A, Replogle J, Laurie M, Liu J, Zha B, et al.
Nat Commun
. 2023 Oct;
14(1):6245.
PMID: 37803001
Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations...
6.
Clark I, Fontanez K, Meltzer R, Xue Y, Hayford C, May-Zhang A, et al.
Nat Biotechnol
. 2023 Mar;
41(11):1557-1566.
PMID: 36879006
Current single-cell RNA-sequencing approaches have limitations that stem from the microfluidic devices or fluid handling steps required for sample processing. We develop a method that does not require specialized microfluidic...
7.
Guna A, Page K, Replogle J, Esantsi T, Wang M, Weissman J, et al.
bioRxiv
. 2023 Jan;
PMID: 36711738
Mapping genetic interactions is essential for determining gene function and defining novel biological pathways. We report a simple to use CRISPR interference (CRISPRi) based platform, compatible with Fluorescence Activated Cell...
8.
Replogle J, Bonnar J, Pogson A, Liem C, Maier N, Ding Y, et al.
Elife
. 2022 Dec;
11.
PMID: 36576240
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell...
9.
Wu D, Poddar A, Ninou E, Hwang E, Cole M, Liu S, et al.
Cell Genom
. 2022 Nov;
2(11).
PMID: 36381608
Human chromosomes are pervasively transcribed, but systematic understanding of coding and lncRNA genome function in cell differentiation is lacking. Using CRISPR interference (CRISPRi) in human induced pluripotent stem cells, we...
10.
Guna A, Stevens T, Inglis A, Replogle J, Esantsi T, Muthukumar G, et al.
Science
. 2022 Oct;
378(6617):317-322.
PMID: 36264797
In the mitochondrial outer membrane, α-helical transmembrane proteins play critical roles in cytoplasmic-mitochondrial communication. Using genome-wide CRISPR screens, we identified mitochondrial carrier homolog 2 (MTCH2), and its paralog MTCH1, and...