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Jonathan S Weissman

Explore the profile of Jonathan S Weissman including associated specialties, affiliations and a list of published articles. Areas
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Articles 258
Citations 51269
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Recent Articles
1.
Qiu X, Zhu D, Lu Y, Yao J, Jing Z, Min K, et al.
Cell . 2025 Mar; PMID: 40024251
No abstract available.
2.
Saunders R, Allen W, Pan X, Sandhu J, Lu J, Lau T, et al.
bioRxiv . 2024 Nov; PMID: 39605605
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the genetic control of...
3.
Wilson C, Pommier G, Richman D, Sambold N, Hussmann J, Weissman J, et al.
bioRxiv . 2024 Nov; PMID: 39554033
Understanding how human gene expression is coordinately regulated by functional units of proteins across the genome remains a major biological goal. Here, we present COMET, a high-throughput screening platform for...
4.
Qiu X, Zhu D, Lu Y, Yao J, Jing Z, Min K, et al.
Cell . 2024 Nov; 187(26):7351-7373.e61. PMID: 39532097
Quantifying spatiotemporal dynamics during embryogenesis is crucial for understanding congenital diseases. We developed Spateo (https://github.com/aristoteleo/spateo-release), a 3D spatiotemporal modeling framework, and applied it to a 3D mouse embryogenesis atlas at...
5.
Jones M, Sun D, Min K, Colgan W, Tian L, Weir J, et al.
bioRxiv . 2024 Nov; PMID: 39484491
Tumor progression is driven by dynamic interactions between cancer cells and their surrounding microenvironment. Investigating the spatiotemporal evolution of tumors can provide crucial insights into how intrinsic changes within cancer...
6.
Deutsch E, Kok L, Mudge J, Ruiz-Orera J, Fierro-Monti I, Sun Z, et al.
bioRxiv . 2024 Sep; PMID: 39314370
A major scientific drive is to characterize the protein-coding genome as it provides the primary basis for the study of human health. But the fundamental question remains: what has been...
7.
Weng C, Weissman J, Sankaran V
bioRxiv . 2024 Sep; PMID: 39229039
The detection of mitochondrial DNA (mtDNA) mutations in single cells holds considerable potential to define clonal relationships coupled with information on cell state in humans. Previous methods focused on higher...
8.
Lam B, Kajderowicz K, Keys H, Roessler J, Frenkel E, Kirkland A, et al.
bioRxiv . 2024 Aug; PMID: 39091747
Cells must adapt to environmental changes to maintain homeostasis. One of the most striking environmental adaptations is entry into hibernation during which core body temperature can decrease from 37°C to...
9.
Nadig A, Replogle J, Pogson A, McCarroll S, Weissman J, Robinson E, et al.
bioRxiv . 2024 Jul; PMID: 39005298
Single cell CRISPR screens such as Perturb-seq enable transcriptomic profiling of genetic perturbations at scale. However, the data produced by these screens are often noisy due to cost and technical...
10.
Neumann E, Bertozzi T, Wu E, Serack F, Harvey J, Brauer P, et al.
Science . 2024 Jun; 384(6703):ado7082. PMID: 38935715
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts prion disease progression....