Marcin Kortylewski
Overview
Explore the profile of Marcin Kortylewski including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hall J, Zhang Z, Wang D, Bhattacharya S, Alcantara M, Liang Y, et al.
bioRxiv
. 2023 Aug;
PMID: 37577590
Decoy-oligodeoxynucleotides (D-ODNs) can target undruggable transcription factors, such as STAT3. However, challenges in D-ODN delivery and potency hampered their translation. To overcome these limitations, we conjugated STAT3-specific D-ODN to thalidomide...
12.
Sharma A, Fernandes D, Reis R, Golubczyk D, Neumann S, Lukomska B, et al.
Cell Biosci
. 2023 Jul;
13(1):137.
PMID: 37501215
The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the...
13.
Kang E, Kortylewski M
Methods Mol Biol
. 2023 Jun;
2691:337-350.
PMID: 37355556
MicroRNA (miRNA) dysregulation is known to be associated with a variety of human diseases, including cancers and immune disorders. MiR146a represents one of the best characterized regulators of the immune...
14.
Ma S, Sun B, Duan S, Han J, Barr T, Zhang J, et al.
Nat Immunol
. 2023 Jan;
24(2):255-266.
PMID: 36658237
Despite tumor-associated macrophages (TAMs) playing a key role in shaping the tumor microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute to cancer progression remain unclear. Here,...
15.
Esposito C, Autiero I, Sandomenico A, Li H, Bassal M, Ibba M, et al.
Nat Commun
. 2023 Jan;
14(1):99.
PMID: 36609400
DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant DNA methylation is the most common molecular lesion in cancer cells. However, medical intervention has been limited to the...
16.
Jordan S, Zielinski M, Kortylewski M, Kuhn T, Bystritsky A
Focus (Am Psychiatr Publ)
. 2022 Jun;
20(1):64-70.
PMID: 35746928
In the past, psychotherapy and neuropharmacological approaches have been the most common treatments for disordered thoughts, moods, and behaviors. One new path of brain therapeutics is in the deployment of...
17.
Dizman N, Meza L, Bergerot P, Alcantara M, Dorff T, Lyou Y, et al.
Nat Med
. 2022 Mar;
28(4):704-712.
PMID: 35228755
Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could...
18.
Frederickson R, Ritter T, Morris K, Kortylewski M, Nasr M, Herzog R
Mol Ther
. 2022 Feb;
30(3):979.
PMID: 35182469
No abstract available.
19.
Adamus T, Hung C, Yu C, Kang E, Hammad M, Flores L, et al.
Mol Ther Nucleic Acids
. 2022 Jan;
27:611-620.
PMID: 35036069
Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and...
20.
Han Z, Estephan R, Wu X, Su C, Yuan Y, Qin H, et al.
J Invest Dermatol
. 2021 Nov;
142(3 Pt A):603-612.e7.
PMID: 34774537
Cutaneous T cell lymphoma (CTCL) is characterized by a background of chronic inflammation, where malignant CTCL cells escape immune surveillance. To study how microRNAs (miRs) regulate T-cell exhaustion, we performed...