Marc S Mendonca
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Explore the profile of Marc S Mendonca including associated specialties, affiliations and a list of published articles.
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58
Citations
857
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Recent Articles
1.
Pirkkanen J, Laframboise T, Peterson J, Labelle A, Mahoney F, Lapointe M, et al.
Radiat Res
. 2024 Aug;
202(4):617-625.
PMID: 39134062
Natural background ionizing radiation is present on the earth's surface; however, the biological role of this chronic low-dose-rate exposure remains unknown. The Researching the Effects of the Presence and Absence...
2.
Mothersill C, Desai R, Seymour C, Mendonca M
Radiat Res
. 2024 Jun;
202(2):205-214.
PMID: 38918004
The aim of this paper is to review the history surrounding the discovery of lethal mutations, later described as delayed reproductive death. Lethal mutations were suggested very early on, to...
3.
Al-Khayyat W, Pirkkanen J, Dougherty J, Laframboise T, Dickinson N, Khaper N, et al.
Cells
. 2023 Oct;
12(19).
PMID: 37830558
FRA1 () is a transcription factor and a member of the superfamily. FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in response to...
4.
Pirkkanen J, Tharmalingam S, Thome C, Sinex H, Benjamin L, Losch A, et al.
Radiat Res
. 2023 May;
200(1):48-64.
PMID: 37141110
The CGL1 human hybrid cell system has been utilized for many decades as an excellent cellular tool for investigating neoplastic transformation. Substantial work has been done previously implicating genetic factors...
5.
Pirkkanen J, Lalonde C, Lapointe M, Laframboise T, Mendonca M, Boreham D, et al.
Radiat Res
. 2023 Feb;
199(3):290-293.
PMID: 36745561
In 2017, a special edition of Radiation Research was published [Oct; Vol. 188 4.2 (https://bioone.org/journals/radiation-research/volume-188/issue-4.2)] which focused on a recently established radiobiology project within SNOLAB, a unique deep-underground research facility....
6.
Jiang L, Liu Y, Su X, Wang J, Zhao Y, Tumbath S, et al.
Front Oncol
. 2022 Oct;
12:976292.
PMID: 36203459
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have exhibited great promise in the treatment of tumors with homologous recombination (HR) deficiency, however, PARPi resistance, which ultimately recovers DNA repair and cell...
7.
Su X, Wang J, Jiang L, Chen Y, Lu T, Mendonca M, et al.
Cancer Lett
. 2021 Jul;
519:304-314.
PMID: 34329742
β-Lapachone is a classic quinone-containing antitumor NQO1-bioactivatable drug that directly kills NQO1-overexpressing cancer cells. However, the clinical applications of β-lapachone are primarily limited by its high toxicity and modest lethality....
8.
Prasanna P, Citrin D, Hildesheim J, Ahmed M, Venkatachalam S, Riscuta G, et al.
J Natl Cancer Inst
. 2021 Apr;
113(10):1285-1298.
PMID: 33792717
Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the...
9.
Huang C, Mendonca M
Clin Cancer Res
. 2020 Dec;
27(3):662-664.
PMID: 33268551
Data indicate that ultrahigh dose rate (>10 Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate that radiation...
10.
Garrett J, Valluri S, Mendonca M, Bigsby R, Lopez J, Caperell-Grant A, et al.
Radiat Res
. 2020 Oct;
194(5):557-565.
PMID: 33045089
Astronauts participating in prolonged space missions constitute a population of individuals who are at an increased risk for cataractogenesis due to exposure to densely ionizing charged particles. Using a rat...