Joseph R Dynlacht
Overview
Explore the profile of Joseph R Dynlacht including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
394
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Recent Articles
1.
Mendoza-Munoz P, Kushwaha N, Chauhan D, Ali Gacem K, Garrett J, Dynlacht J, et al.
Cancers (Basel)
. 2024 Oct;
16(19).
PMID: 39409907
: DNA-dependent protein kinase (DNA-PK) is a validated cancer therapeutic target involved in DNA damage response (DDR) and non-homologous end-joining (NHEJ) repair of DNA double-strand breaks (DSBs). Ku serves as...
2.
Dynlacht J, Wallach P, Chenworth T, Blumenthal D
Radiat Res
. 2024 Sep;
202(3):599-604.
PMID: 39245466
No abstract available.
3.
Mendoza-Munoz P, Gavande N, VanderVere-Carozza P, Pawelczak K, Dynlacht J, Garrett J, et al.
NAR Cancer
. 2023 Feb;
5(1):zcad003.
PMID: 36755959
The DNA-dependent protein kinase (DNA-PK) plays a critical role in the DNA damage response (DDR) and non-homologous end joining (NHEJ) double-strand break (DSB) repair pathways. Consequently, DNA-PK is a validated...
4.
Garrett J, Metzger E, Dewhirst M, Pollok K, Turchi J, Le Poole I, et al.
Int J Hyperthermia
. 2022 Mar;
39(1):405-413.
PMID: 35236209
Background: Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate produced from Bergman cyclization of the enediyne...
5.
Ainsbury E, Dalke C, Mancuso M, Kadhim M, Quinlan R, Azizova T, et al.
Radiat Res
. 2021 Nov;
197(1):1-6.
PMID: 34788470
Recent epidemiological and experimental animal data, as well as reanalyses of data previously accumulated, indicate that the lens of the eye is more radiosensitive than was previously thought. This has...
6.
Gavande N, VanderVere-Carozza P, Pawelczak K, Mendoza-Munoz P, Vernon T, Hanakahi L, et al.
Nucleic Acids Res
. 2020 Oct;
48(20):11536-11550.
PMID: 33119767
DNA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage response (DDR). DNA-PK has therefore been pursued for the development...
7.
Garrett J, Valluri S, Mendonca M, Bigsby R, Lopez J, Caperell-Grant A, et al.
Radiat Res
. 2020 Oct;
194(5):557-565.
PMID: 33045089
Astronauts participating in prolonged space missions constitute a population of individuals who are at an increased risk for cataractogenesis due to exposure to densely ionizing charged particles. Using a rat...
8.
Garrett J, Metzger E, Schmitt K, Soto S, Northern S, Kryah L, et al.
Radiat Res
. 2019 Dec;
193(2):107-118.
PMID: 31800359
Enediyne natural products are a class of compounds that were recognized for their potential as chemotherapeutic agents many years ago, but found to be highly cytotoxic due to their propensity...
9.
Garrett J, Sampson C, Plett P, Crisler R, Parker J, Venezia R, et al.
Radiat Res
. 2018 Oct;
191(1):31-42.
PMID: 30339056
Several investigators performing bone marrow transplantation studies have previously reported sporadic increases in mortality that were associated with pronounced swelling in the face, head and neck of mice. Over the...
10.
Keller E, Porter M, Garrett J, Varie M, Wang H, Pollok K, et al.
Radiat Res
. 2018 May;
190(2):107-116.
PMID: 29763378
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity. We previously demonstrated that cytotoxicity of two different metalloenediynes,...