Marc N Wein
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Explore the profile of Marc N Wein including associated specialties, affiliations and a list of published articles.
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59
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1768
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Recent Articles
11.
Moradi Tuchayi S, Khachatryan Y, Wang Y, Anderson R, Wang J, Wein M, et al.
Sci Rep
. 2023 Sep;
13(1):16350.
PMID: 37770553
Reduction in visceral adipose tissue (VAT) mass reduces body weight and metabolic disease risk in obese patients. However surgical removal of VAT is highly invasive and thus not clinically feasible....
12.
Wang J, Tokavanich N, Wein M
Curr Osteoporos Rep
. 2023 Mar;
21(2):241-252.
PMID: 36881265
Purpose Of Review: The purpose of this review is to summarize the different roles of the transcription factor SP7 in regulating bone formation and remodeling, discuss current studies in investigating...
13.
Yoon S, Meyer M, Arevalo C, Tekguc M, Zhang C, Wang J, et al.
J Clin Invest
. 2023 Mar;
133(9).
PMID: 36862513
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs)...
14.
Zhou W, Simic P, Zhou I, Caravan P, Parada X, Wen D, et al.
J Clin Invest
. 2023 Feb;
133(8).
PMID: 36821389
How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but...
15.
Sato T, Castro Andrade C, Yoon S, Zhao Y, Greenlee W, Weber P, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(50):e2214396119.
PMID: 36472957
Osteoporosis is a major public health problem. Currently, there are no orally available therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates bone formation through a signal transduction pathway...
16.
Meyer M, Benkusky N, Lee S, Yoon S, Mannstadt M, Wein M, et al.
J Biol Chem
. 2022 Oct;
298(11):102559.
PMID: 36183832
Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones, including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor 23 (FGF23) and 1,25-dihydroxyvitamin D (1,25(OH)D), and...
17.
Mazur C, Castro Andrade C, Tokavanich N, Sato T, Bruce M, Brooks D, et al.
iScience
. 2022 Sep;
25(9):105019.
PMID: 36105586
Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility. Preventing apoptosis and...
18.
Wang J, Wein M
Curr Osteoporos Rep
. 2022 Sep;
20(6):493-504.
PMID: 36087214
Purpose Of Review: The purpose of this review is to discuss the molecular mechanisms involved in osteocyte dendrite formation, summarize the similarities between osteocytic and neuronal projections, and highlight the...
19.
Yoon S, Tang C, Wein M
Vitam Horm
. 2022 Aug;
120:23-45.
PMID: 35953111
Parathyroid hormone is a central regulator of calcium homeostasis. PTH protects the organism from hypocalcemia through its actions in bone and kidney. Recent physiologic studies have revealed key target genes...
20.
Tokavanich N, Wein M, English J, Ono N, Ono W
Front Dent Med
. 2022 Jul;
2.
PMID: 35782525
Appropriate tooth root formation and tooth eruption are critical for achieving and maintaining good oral health and quality of life. Tooth eruption is the process through which teeth emerge from...