Manzar Hossain
Overview
Explore the profile of Manzar Hossain including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
149
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0
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Recent Articles
1.
Hossain M, Bhalla K, Stillman B
Mol Cell
. 2021 Mar;
81(9):1951-1969.e6.
PMID: 33761311
The initiation of DNA replication involves cell cycle-dependent assembly and disassembly of protein complexes, including the origin recognition complex (ORC) and CDC6 AAA ATPases. We report that multiple short linear...
2.
Tramentozzi E, Ferraro P, Hossain M, Stillman B, Bianchi V, Pontarin G
Cell Cycle
. 2018 Jul;
17(9):1102-1114.
PMID: 30039733
SAMHD1 is the major catabolic enzyme regulating the intracellular concentrations of DNA precursors (dNTPs). The S-phase kinase CDK2-cyclinA phosphorylates SAMHD1 at Thr-592. How this modification affects SAMHD1 function is highly...
3.
Hossain M, Stillman B
Elife
. 2016 Jul;
5.
PMID: 27458800
Newly born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication. ORC1, the Origin Recognition Complex...
4.
Kara N, Hossain M, Prasanth S, Stillman B
J Biol Chem
. 2015 Mar;
290(19):12355-69.
PMID: 25784553
Replication of eukaryotic chromosomes occurs once every cell division cycle in normal cells and is a tightly controlled process that ensures complete genome duplication. The origin recognition complex (ORC) plays...
5.
Hossain M, Sharma S, Korde R, Kanodia S, Chugh M, Rawat K, et al.
Malar J
. 2013 Sep;
12:333.
PMID: 24047207
Background: Splicing and alternate splicing are the two key biological processes that result in the generation of diverse transcript and protein isoforms in Plasmodium falciparum as well as in other...
6.
Hossain M, Stillman B
Genes Dev
. 2012 Aug;
26(16):1797-810.
PMID: 22855792
Like DNA replication, centrosomes are licensed to duplicate once per cell division cycle to ensure genetic stability. In addition to regulating DNA replication, the Orc1 subunit of the human origin...